| Literature DB >> 23297848 |
Romain Haudecoeur1, Loic Stefan, Franck Denat, David Monchaud.
Abstract
An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first "smart G-quadruplex ligand" is reported, since this ligand experiences a structural change in the presence of quadruplexes but not in the presence of duplexes, ensuring a high level of quadruplex selectivity.Mesh：
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Year: 2013 PMID： 23297848 DOI： 10.1021/ja310056y
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419