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Literature DB >> 23296676

Assessing organismal aging in the filamentous fungus Podospora anserina.

Heinz D Osiewacz¹, Andrea Hamann, Sandra Zintel.

Abstract

Podospora anserina is an extensively studied model organism to unravel the mechanism of organismal aging. This filamentous fungus is short-lived and accessible to experimentation. Aging and lifespan are controlled by genetic and environmental traits and, in this model, have a strong mitochondrial etiology. Here, we describe methods and protocols to manipulate and study the aging process in P. anserina at different levels including biochemistry, cell biology, genetics, and physiology.

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Year: 2013 PMID： 23296676 DOI： 10.1007/978-1-62703-239-1_29

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

24 in total

1. Overexpression of Pa_1_10620 encoding a mitochondrial Podospora anserina protein with homology to superoxide dismutases and ribosomal proteins leads to lifespan extension.

Authors: Carolin Grimm; Lena Böhl; Heinz D Osiewacz
Journal: Curr Genet Date: 2014-08-24 Impact factor: 3.886

Review 2. Control of mitochondrial integrity in ageing and disease.

Authors: Radek Szklarczyk; Marco Nooteboom; Heinz D Osiewacz
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2014-07-05 Impact factor: 6.237

3. CLiB - a novel cardiolipin-binder isolated via data-driven and in vitro screening.

Authors: Isabel Kleinwächter; Bernadette Mohr; Aljoscha Joppe; Nadja Hellmann; Tristan Bereau; Heinz D Osiewacz; Dirk Schneider
Journal: RSC Chem Biol Date: 2022-06-10

4. Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.

Authors: Ingmar Strobel; Heinz D Osiewacz
Journal: Eukaryot Cell Date: 2013-04-12

5. Global Protein Oxidation Profiling Suggests Efficient Mitochondrial Proteome Homeostasis During Aging.

Authors: Carina Ramallo Guevara; Oliver Philipp; Andrea Hamann; Alexandra Werner; Heinz D Osiewacz; Sascha Rexroth; Matthias Rögner; Ansgar Poetsch
Journal: Mol Cell Proteomics Date: 2016-02-16 Impact factor: 5.911

6. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.

Authors: Nina Meyer; Svenja Zielke; Jonas B Michaelis; Benedikt Linder; Verena Warnsmann; Stefanie Rakel; Heinz D Osiewacz; Simone Fulda; Michel Mittelbronn; Christian Münch; Christian Behrends; Donat Kögel
Journal: Autophagy Date: 2018-07-21 Impact factor: 16.016

Assessing organismal aging in the filamentous fungus Podospora anserina.

1. Overexpression of Pa_1_10620 encoding a mitochondrial Podospora anserina protein with homology to superoxide dismutases and ribosomal proteins leads to lifespan extension.

Review 2. Control of mitochondrial integrity in ageing and disease.

3. CLiB - a novel cardiolipin-binder isolated via data-driven and in vitro screening.

4. Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.

5. Global Protein Oxidation Profiling Suggests Efficient Mitochondrial Proteome Homeostasis During Aging.

6. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.

7. The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina.

8. Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging.

9. A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.

10. Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins.