Literature DB >> 23296178

Bone metabolism in 2012: Novel osteoporosis targets.

Claes Ohlsson1.   

Abstract

Researchers are trying to develop more efficient and safer antifracture treatments. Besides the ongoing promising clinical trials involving antibodies to the Wnt antagonist sclerostin or inhibition of the osteoclast enzyme cathepsin K, the year 2012 has seen several novel osteoporosis targets identified by using different methodological approaches.

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Year:  2013        PMID： 23296178     DOI： 10.1038/nrendo.2012.252

Source DB:  PubMed          Journal:  Nat Rev Endocrinol        ISSN： 1759-5029            Impact factor:   43.330


  10 in total

1.  Translational medicine: Double protection for weakened bones.

Authors:  Mone Zaidi; Jameel Iqbal
Journal:  Nature       Date:  2012-05-02       Impact factor: 49.962

Review 2.  Genetics of osteoporosis.

Authors:  Stuart H Ralston; André G Uitterlinden
Journal:  Endocr Rev       Date:  2010-04-29       Impact factor: 19.871

3.  Osteoprotection by semaphorin 3A.

Authors:  Mikihito Hayashi; Tomoki Nakashima; Masahiko Taniguchi; Tatsuhiko Kodama; Atsushi Kumanogoh; Hiroshi Takayanagi
Journal:  Nature       Date:  2012-05-03       Impact factor: 49.962

4.  Antibiotics in early life alter the murine colonic microbiome and adiposity.

Authors:  Ilseung Cho; Shingo Yamanishi; Laura Cox; Barbara A Methé; Jiri Zavadil; Kelvin Li; Zhan Gao; Douglas Mahana; Kartik Raju; Isabel Teitler; Huilin Li; Alexander V Alekseyenko; Martin J Blaser
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

5.  Fracture risk and zoledronic acid therapy in men with osteoporosis.

Authors:  Steven Boonen; Jean-Yves Reginster; Jean-Marc Kaufman; Kurt Lippuner; Jose Zanchetta; Bente Langdahl; Rene Rizzoli; Stanley Lipschitz; Hans Peter Dimai; Richard Witvrouw; Erik Eriksen; Kim Brixen; Luis Russo; Frank Claessens; Philemon Papanastasiou; Oscar Antunez; Guoqin Su; Christina Bucci-Rechtweg; Josef Hruska; Elodie Incera; Dirk Vanderschueren; Eric Orwoll
Journal:  N Engl J Med       Date:  2012-11-01       Impact factor: 91.245

6.  Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD.

Authors:  Toby Andrew; Leto Antioniades; Katrina J Scurrah; Alex J Macgregor; Tim D Spector
Journal:  J Bone Miner Res       Date:  2004-10-25       Impact factor: 6.741

7.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Authors:  Karol Estrada; Unnur Styrkarsdottir; Evangelos Evangelou; Yi-Hsiang Hsu; Emma L Duncan; Evangelia E Ntzani; Ling Oei; Omar M E Albagha; Najaf Amin; John P Kemp; Daniel L Koller; Guo Li; Ching-Ti Liu; Ryan L Minster; Alireza Moayyeri; Liesbeth Vandenput; Dana Willner; Su-Mei Xiao; Laura M Yerges-Armstrong; Hou-Feng Zheng; Nerea Alonso; Joel Eriksson; Candace M Kammerer; Stephen K Kaptoge; Paul J Leo; Gudmar Thorleifsson; Scott G Wilson; James F Wilson; Ville Aalto; Markku Alen; Aaron K Aragaki; Thor Aspelund; Jacqueline R Center; Zoe Dailiana; David J Duggan; Melissa Garcia; Natàlia Garcia-Giralt; Sylvie Giroux; Göran Hallmans; Lynne J Hocking; Lise Bjerre Husted; Karen A Jameson; Rita Khusainova; Ghi Su Kim; Charles Kooperberg; Theodora Koromila; Marcin Kruk; Marika Laaksonen; Andrea Z Lacroix; Seung Hun Lee; Ping C Leung; Joshua R Lewis; Laura Masi; Simona Mencej-Bedrac; Tuan V Nguyen; Xavier Nogues; Millan S Patel; Janez Prezelj; Lynda M Rose; Serena Scollen; Kristin Siggeirsdottir; Albert V Smith; Olle Svensson; Stella Trompet; Olivia Trummer; Natasja M van Schoor; Jean Woo; Kun Zhu; Susana Balcells; Maria Luisa Brandi; Brendan M Buckley; Sulin Cheng; Claus Christiansen; Cyrus Cooper; George Dedoussis; Ian Ford; Morten Frost; David Goltzman; Jesús González-Macías; Mika Kähönen; Magnus Karlsson; Elza Khusnutdinova; Jung-Min Koh; Panagoula Kollia; Bente Lomholt Langdahl; William D Leslie; Paul Lips; Östen Ljunggren; Roman S Lorenc; Janja Marc; Dan Mellström; Barbara Obermayer-Pietsch; José M Olmos; Ulrika Pettersson-Kymmer; David M Reid; José A Riancho; Paul M Ridker; François Rousseau; P Eline Slagboom; Nelson L S Tang; Roser Urreizti; Wim Van Hul; Jorma Viikari; María T Zarrabeitia; Yurii S Aulchenko; Martha Castano-Betancourt; Elin Grundberg; Lizbeth Herrera; Thorvaldur Ingvarsson; Hrefna Johannsdottir; Tony Kwan; Rui Li; Robert Luben; Carolina Medina-Gómez; Stefan Th Palsson; Sjur Reppe; Jerome I Rotter; Gunnar Sigurdsson; Joyce B J van Meurs; Dominique Verlaan; Frances M K Williams; Andrew R Wood; Yanhua Zhou; Kaare M Gautvik; Tomi Pastinen; Soumya Raychaudhuri; Jane A Cauley; Daniel I Chasman; Graeme R Clark; Steven R Cummings; Patrick Danoy; Elaine M Dennison; Richard Eastell; John A Eisman; Vilmundur Gudnason; Albert Hofman; Rebecca D Jackson; Graeme Jones; J Wouter Jukema; Kay-Tee Khaw; Terho Lehtimäki; Yongmei Liu; Mattias Lorentzon; Eugene McCloskey; Braxton D Mitchell; Kannabiran Nandakumar; Geoffrey C Nicholson; Ben A Oostra; Munro Peacock; Huibert A P Pols; Richard L Prince; Olli Raitakari; Ian R Reid; John Robbins; Philip N Sambrook; Pak Chung Sham; Alan R Shuldiner; Frances A Tylavsky; Cornelia M van Duijn; Nick J Wareham; L Adrienne Cupples; Michael J Econs; David M Evans; Tamara B Harris; Annie Wai Chee Kung; Bruce M Psaty; Jonathan Reeve; Timothy D Spector; Elizabeth A Streeten; M Carola Zillikens; Unnur Thorsteinsdottir; Claes Ohlsson; David Karasik; J Brent Richards; Matthew A Brown; Kari Stefansson; André G Uitterlinden; Stuart H Ralston; John P A Ioannidis; Douglas P Kiel; Fernando Rivadeneira
Journal:  Nat Genet       Date:  2012-04-15       Impact factor: 38.330

8.  The gut microbiota regulates bone mass in mice.

Authors:  Klara Sjögren; Cecilia Engdahl; Petra Henning; Ulf H Lerner; Valentina Tremaroli; Marie K Lagerquist; Fredrik Bäckhed; Claes Ohlsson
Journal:  J Bone Miner Res       Date:  2012-06       Impact factor: 6.741

9.  Evolution of mammals and their gut microbes.

Authors:  Ruth E Ley; Micah Hamady; Catherine Lozupone; Peter J Turnbaugh; Rob Roy Ramey; J Stephen Bircher; Michael L Schlegel; Tammy A Tucker; Mark D Schrenzel; Rob Knight; Jeffrey I Gordon
Journal:  Science       Date:  2008-05-22       Impact factor: 47.728

10.  WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Authors:  Hou-Feng Zheng; Jon H Tobias; Emma Duncan; David M Evans; Joel Eriksson; Lavinia Paternoster; Laura M Yerges-Armstrong; Terho Lehtimäki; Ulrica Bergström; Mika Kähönen; Paul J Leo; Olli Raitakari; Marika Laaksonen; Geoffrey C Nicholson; Jorma Viikari; Martin Ladouceur; Leo-Pekka Lyytikäinen; Carolina Medina-Gomez; Fernando Rivadeneira; Richard L Prince; Harri Sievanen; William D Leslie; Dan Mellström; John A Eisman; Sofia Movérare-Skrtic; David Goltzman; David A Hanley; Graeme Jones; Beate St Pourcain; Yongjun Xiao; Nicholas J Timpson; George Davey Smith; Ian R Reid; Susan M Ring; Philip N Sambrook; Magnus Karlsson; Elaine M Dennison; John P Kemp; Patrick Danoy; Adrian Sayers; Scott G Wilson; Maria Nethander; Eugene McCloskey; Liesbeth Vandenput; Richard Eastell; Jeff Liu; Tim Spector; Braxton D Mitchell; Elizabeth A Streeten; Robert Brommage; Ulrika Pettersson-Kymmer; Matthew A Brown; Claes Ohlsson; J Brent Richards; Mattias Lorentzon
Journal:  PLoS Genet       Date:  2012-07-05       Impact factor: 5.917
  10 in total
  7 in total

1.  Prevention of alveolar bone loss in an osteoporotic animal model via interference of semaphorin 4d.

Authors:  Y Zhang; L Wei; R J Miron; Q Zhang; Z Bian
Journal:  J Dent Res       Date:  2014-09-24       Impact factor: 6.116

2.  Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects.

Authors:  Joel Eriksson; Daniel S Evans; Carrie M Nielson; Jian Shen; Priya Srikanth; Marc Hochberg; Shannon McWeeney; Peggy M Cawthon; Beth Wilmot; Joseph Zmuda; Greg Tranah; Daniel B Mirel; Sashi Challa; Michael Mooney; Andrew Crenshaw; Magnus Karlsson; Dan Mellström; Liesbeth Vandenput; Eric Orwoll; Claes Ohlsson
Journal:  J Bone Miner Res       Date:  2015-01       Impact factor: 6.741

Review 3.  The neurobiology of skeletal pain.

Authors:  Patrick W Mantyh
Journal:  Eur J Neurosci       Date:  2014-02       Impact factor: 3.386

4.  Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice.

Authors:  Michelle L Thompson; Juan Miguel Jimenez-Andrade; Patrick W Mantyh
Journal:  J Histochem Cytochem       Date:  2015-12-23       Impact factor: 2.479

5.  Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone.

Authors:  Xinlong Ma; Jianwei Lv; Xiaolei Sun; Jianxiong Ma; Guosheng Xing; Ying Wang; Lei Sun; Jianbao Wang; Fengbo Li; Yanjun Li; Zhihu Zhao
Journal:  Sci Rep       Date:  2016-04-25       Impact factor: 4.379

6.  Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects.

Authors:  Yufeng Zhang; Lingfei Wei; Richard J Miron; Bin Shi; Zhuan Bian
Journal:  Sci Rep       Date:  2016-06-02       Impact factor: 4.379

7.  BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure.

Authors:  Maria Nethander; Ulrika Pettersson-Kymmer; Liesbeth Vandenput; Mattias Lorentzon; Magnus Karlsson; Dan Mellström; Claes Ohlsson
Journal:  J Clin Endocrinol Metab       Date:  2020-04-01       Impact factor: 5.958
  7 in total

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