INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
Authors: Ana Luisa Quintella do Couto Aleixo; Raquel Vasconcelos C de Oliveira; Maíra Cavalcanti Albuquerque; Ana Luiza Biancardi; André Luiz Land Curi; Eliezer Israel Benchimol; Maria Regina Reis Amendoeira Journal: PLoS One Date: 2019-02-12 Impact factor: 3.240
Authors: Ricardo Guerra Peixe; Marcela Santana Bastos Boechat; Alba Lucinia Peixoto Rangel; Rhônia França Gomes Rosa; Maria Luiza Petzl-Erler; Lilian M G Bahia-Oliveira Journal: Mem Inst Oswaldo Cruz Date: 2014-02 Impact factor: 2.743
Authors: Paula Keiko Sato; Felipe Delatorre Busser; Flávia Mendes da Cunha Carvalho; Alexandra Gomes Dos Santos; Aya Sadahiro; Constancia Lima Diogo; Adriana Satie Gonçalves Kono; Maria Luiza Moretti; Olinda do Carmo Luiz; Maria Aparecida Shikanai-Yasuda Journal: Front Immunol Date: 2020-10-01 Impact factor: 7.561