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Literature DB >> 23295701

Methotrexate: underused and ignored?

Hans H Herfarth¹, Millie D Long, Kim L Isaacs.

Abstract

For more than a decade, methotrexate has been known to be an effective therapeutic agent in the treatment of steroid-dependent active Crohn's disease. However, international data on medication utilization suggest that this drug is rarely used in clinical practice for an indication of Crohn's disease. This review investigates the potential reasons for the underuse of methotrexate in patients with inflammatory bowel diseases.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Azathioprine
Methotrexate

Year: 2013 PMID： 23295701 PMCID： PMC4629813 DOI： 10.1159/000342735

Source DB: PubMed Journal: Dig Dis ISSN： 0257-2753 Impact factor: 2.404

51 in total

1. Management of Crohn's disease in adults.

Authors: Gary R Lichtenstein; Stephen B Hanauer; William J Sandborn
Journal: Am J Gastroenterol Date: 2009-01-06 Impact factor: 10.864

2. Liver fibrosis in patients with psoriasis and psoriatic arthritis on long-term, high cumulative dose methotrexate therapy.

Authors: Karen Lindsay; Alexander D Fraser; Alison Layton; Mark Goodfield; Hans Gruss; Andrew Gough
Journal: Rheumatology (Oxford) Date: 2009-03-09 Impact factor: 7.580

3. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference.

Authors: Robert E Kalb; Bruce Strober; Gerald Weinstein; Mark Lebwohl
Journal: J Am Acad Dermatol Date: 2009-05 Impact factor: 11.527

Review 4. Management of the pregnant IBD patient.

Authors: Marla Dubinsky; Bincy Abraham; Uma Mahadevan
Journal: Inflamm Bowel Dis Date: 2008-12 Impact factor: 5.325

Review 5. Methotrexate for maintenance of remission in Crohn's disease.

Authors: Vishal Patel; John K Macdonald; John Wd McDonald; Nilesh Chande
Journal: Cochrane Database Syst Rev Date: 2009-10-07

6. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators.

Authors: B G Feagan; J Rochon; R N Fedorak; E J Irvine; G Wild; L Sutherland; A H Steinhart; G R Greenberg; R Gillies; M Hopkins
Journal: N Engl J Med Date: 1995-02-02 Impact factor: 91.245

Review 7. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.

Authors: Eliza Prefontaine; Lloyd R Sutherland; John K Macdonald; Monica Cepoiu
Journal: Cochrane Database Syst Rev Date: 2009-01-21

Review 8. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature.

Authors: K Visser; D van der Heijde
Journal: Ann Rheum Dis Date: 2008-11-25 Impact factor: 19.103

9. Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative.

Authors: K Visser; W Katchamart; E Loza; J A Martinez-Lopez; C Salliot; J Trudeau; C Bombardier; L Carmona; D van der Heijde; J W J Bijlsma; D T Boumpas; H Canhao; C J Edwards; V Hamuryudan; T K Kvien; B F Leeb; E M Martín-Mola; H Mielants; U Müller-Ladner; G Murphy; M Østergaard; I A Pereira; C Ramos-Remus; G Valentini; J Zochling; M Dougados
Journal: Ann Rheum Dis Date: 2008-11-25 Impact factor: 19.103

Review 10. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research.

Authors: C Salliot; D van der Heijde
Journal: Ann Rheum Dis Date: 2008-12-05 Impact factor: 19.103

6 in total

Methotrexate: underused and ignored?

1. Management of Crohn's disease in adults.

2. Liver fibrosis in patients with psoriasis and psoriatic arthritis on long-term, high cumulative dose methotrexate therapy.

3. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference.

Review 4. Management of the pregnant IBD patient.

Review 5. Methotrexate for maintenance of remission in Crohn's disease.

6. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators.

Review 7. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.

Review 8. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature.

9. Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative.

Review 10. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research.

Review 1. Methotrexate for Inflammatory Bowel Diseases - New Developments.

2. miR-770-5p modulates resistance to methotrexate in human colorectal adenocarcinoma cells by downregulating HIPK1.

Review 3. Advantages of combined photodynamic therapy in the treatment of oncological diseases.

Review 4. Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases.

Review 5. Medical Therapy in Chronic Refractory Ulcerative Colitis: When Enough Is Enough.

6. Induction of Erythrocyte Membrane Blebbing by Methotrexate-Induced Oxidative Stress.