Mohamed El Molla1, Tamadur Mahasneh2, Sue-Ellen Holmes3, Darweesh Al-Khawaja4. 1. Neurosurgical Department, Wollongong Hospital, University of Wollongong, Wollongong, New South Wales, Australia. 2. Anatomical Pathology Department, Liverpool Hospital, Liverpool, New South Wales, Australia. 3. Private Neurosurgical Practice, New South Wales, Australia. 4. Neurosurgical Department, Wollongong Hospital, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address: braindoc@tpg.com.au.
Abstract
BACKGROUND: Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, is a rare, benign, lymphoproliferative disorder that commonly manifests as a massive painless cervical lymphadenopathy with associated fever and weight loss. Central nervous system involvement is extremely rare, and cervical spinal cord manifestation has not been reported. METHODS: A 76-year-old man presented with a 10-week history of right hemiparesis. Magnetic resonance imaging identified an enhancing cervical intramedullary lesion consistent with a primary spinal cord tumor. RESULTS: Histopathology revealed intramedullary histiocytosis. CONCLUSIONS: This cervical presentation of Rosai-Dorfman disease with central nervous system involvement suggests variation in the clinical manifestations of the disease, necessitating greater surgical awareness. Crown
BACKGROUND:Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, is a rare, benign, lymphoproliferative disorder that commonly manifests as a massive painless cervical lymphadenopathy with associated fever and weight loss. Central nervous system involvement is extremely rare, and cervical spinal cord manifestation has not been reported. METHODS: A 76-year-old man presented with a 10-week history of right hemiparesis. Magnetic resonance imaging identified an enhancing cervical intramedullary lesion consistent with a primary spinal cord tumor. RESULTS: Histopathology revealed intramedullary histiocytosis. CONCLUSIONS: This cervical presentation of Rosai-Dorfman disease with central nervous system involvement suggests variation in the clinical manifestations of the disease, necessitating greater surgical awareness. Crown
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