BACKGROUND: In elderly patients the management of psoriasis is challenging due to contraindications and a higher risk of side effects. OBJECTIVE: Our retrospective study aimed to evaluate the long-term efficacy and safety profile of subcutaneous anti-tumor necrosis factor (anti-TNF) agents in elderly psoriatic patients. METHODS: The study included 89 patients (aged ≥65 years) with plaque-type psoriasis and psoriatic arthritis treated with the subcutaneous anti-TNF-α agents etanercept or adalimumab as monotherapy for a long-term continuous period. RESULTS: Efficacy results were consistent and stable over long-term observation, as expressed by mean Psoriasis Area and Severity Index (PASI) score variation, percentage of patients achieving PASI50 and PASI75 and by the improvement of articular indices, pain visual analogue scale (Pain-VAS) and 44-Joint Disease Activity Score (DAS44-ESR). The proportion of patients achieving PASI50 was 91.80 and 82.14% at week 156 with etanercept and adalimumab treatment, respectively, while the proportion of patients achieving PASI75 was 83.61 and 71.43% at week 156 when treated with etanercept and adalimumab, respectively. The mean DAS44-ESR score decreased from 5.80 to 0.89 and from 3.43 to 1.44 at week 156 and the mean Pain-VAS score decreased from 75.10 to 3.15 and from 71.30 to 18.26 at week 156 with etanercept and adalimumab treatment, respectively. Both treatment adherence and safety profile were good. CONCLUSIONS: Our study demonstrates that subcutaneous anti-TNF-α agents are appropriate in the long-term management of elderly patients.
BACKGROUND: In elderly patients the management of psoriasis is challenging due to contraindications and a higher risk of side effects. OBJECTIVE: Our retrospective study aimed to evaluate the long-term efficacy and safety profile of subcutaneous anti-tumornecrosis factor (anti-TNF) agents in elderly psoriaticpatients. METHODS: The study included 89 patients (aged ≥65 years) with plaque-type psoriasis and psoriatic arthritis treated with the subcutaneous anti-TNF-α agents etanercept or adalimumab as monotherapy for a long-term continuous period. RESULTS: Efficacy results were consistent and stable over long-term observation, as expressed by mean Psoriasis Area and Severity Index (PASI) score variation, percentage of patients achieving PASI50 and PASI75 and by the improvement of articular indices, pain visual analogue scale (Pain-VAS) and 44-Joint Disease Activity Score (DAS44-ESR). The proportion of patients achieving PASI50 was 91.80 and 82.14% at week 156 with etanercept and adalimumab treatment, respectively, while the proportion of patients achieving PASI75 was 83.61 and 71.43% at week 156 when treated with etanercept and adalimumab, respectively. The mean DAS44-ESR score decreased from 5.80 to 0.89 and from 3.43 to 1.44 at week 156 and the mean Pain-VAS score decreased from 75.10 to 3.15 and from 71.30 to 18.26 at week 156 with etanercept and adalimumab treatment, respectively. Both treatment adherence and safety profile were good. CONCLUSIONS: Our study demonstrates that subcutaneous anti-TNF-α agents are appropriate in the long-term management of elderly patients.
Authors: P Conigliaro; P Triggianese; C Perricone; M S Chimenti; G Di Muzio; E Ballanti; M D Guarino; B Kroegler; G Gigliucci; S Grelli; R Perricone Journal: Clin Exp Immunol Date: 2014-07 Impact factor: 4.330
Authors: Francesco Caso; Marco Tasso; Maria Sole Chimenti; Luca Navarini; Carlo Perricone; Nicolò Girolimetto; Rosario Peluso; Antonio Del Puente; Antonella Afeltra; Roberto Perricone; Leonardo Punzi; Raffaele Scarpa; Luisa Costa Journal: Drugs Aging Date: 2019-10 Impact factor: 3.923
Authors: Maria Sole Chimenti; Paola Triggianese; Alessandra Narcisi; Barbara Marinari; Miriam Teoli; Sara Faleri; Annalisa Arcese; Roberto Perricone; Antonio Costanzo Journal: J Int Med Res Date: 2016-09 Impact factor: 1.671