OBJECTIVE: Abdominal surgery invariably causes a temporary reduction of normal intestinal motility, called postoperative ileus. Postoperative ileus extends hospital stays, increases the costs of hospitalization, and may contribute to the formation of postoperative adhesions. We designed experiments to determine if visceral massage affects postoperative ileus in a rat model. MATERIAL AND METHODS: Forty female Long Evans rats were assigned to 4 groups in a 2 (surgery) × 2 (treatment) factorial design. Twenty rats were subjected to a small intestinal manipulation designed to emulate "running of the bowel." Transabdominal massage was performed upon 10 operated and 10 control rats in the first 12 h following surgery. Ileus was assayed after 24 h using fecal pellet discharge and gastrointestinal transit. Intraperitoneal inflammation was assayed using total intraperitoneal protein and inflammatory cell concentrations. RESULTS: The surgery consistently caused ileus. Compared to the operated group with no treatment, the operated with treatment group showed increased gastrointestinal transit and reduced time to first fecal pellet discharge. Similar group comparisons revealed that the treatment decreased total intraperitoneal protein and numbers of intraperitoneal inflammatory cells. CONCLUSIONS: In this rat model, visceral massage reduced experimental postoperative ileus. The data suggest that the effect was through the attenuation of inflammation. A similar study could be designed and performed in a hospital setting to assess the potential role of visceral massage as part of the integrated care for postoperative ileus.
OBJECTIVE: Abdominal surgery invariably causes a temporary reduction of normal intestinal motility, called postoperative ileus. Postoperative ileus extends hospital stays, increases the costs of hospitalization, and may contribute to the formation of postoperative adhesions. We designed experiments to determine if visceral massage affects postoperative ileus in a rat model. MATERIAL AND METHODS: Forty female Long Evans rats were assigned to 4 groups in a 2 (surgery) × 2 (treatment) factorial design. Twenty rats were subjected to a small intestinal manipulation designed to emulate "running of the bowel." Transabdominal massage was performed upon 10 operated and 10 control rats in the first 12 h following surgery. Ileus was assayed after 24 h using fecal pellet discharge and gastrointestinal transit. Intraperitoneal inflammation was assayed using total intraperitoneal protein and inflammatory cell concentrations. RESULTS: The surgery consistently caused ileus. Compared to the operated group with no treatment, the operated with treatment group showed increased gastrointestinal transit and reduced time to first fecal pellet discharge. Similar group comparisons revealed that the treatment decreased total intraperitoneal protein and numbers of intraperitoneal inflammatory cells. CONCLUSIONS: In this rat model, visceral massage reduced experimental postoperative ileus. The data suggest that the effect was through the attenuation of inflammation. A similar study could be designed and performed in a hospital setting to assess the potential role of visceral massage as part of the integrated care for postoperative ileus.
Authors: Amanda D Rice; Kimberley Patterson; Evette D Reed; Belinda F Wurn; Bernhard Klingenberg; C Richard King; Lawrence J Wurn Journal: Biomed Res Int Date: 2016-02-18 Impact factor: 3.411
Authors: Sang Pyo Lee; Oh Young Lee; Kang Nyeong Lee; Hang Lak Lee; Ho Soon Choi; Byung Chul Yoon; Dae Won Jun Journal: J Neurogastroenterol Motil Date: 2017-01-30 Impact factor: 4.924
Authors: Amanda D Rice; Kimberley Patterson; Evette D Reed; Belinda F Wurn; Kristen Robles; Bernhard Klingenberg; Leonard B Weinstock; Janey Sa Pratt; C Richard King; Lawrence J Wurn Journal: World J Gastroenterol Date: 2018-05-21 Impact factor: 5.742
Authors: Geoffrey M Bove; Susan L Chapelle; Katherine E Hanlon; Michael P Diamond; David J Mokler Journal: PLoS One Date: 2017-06-02 Impact factor: 3.240