Allogeneic transplantation of fetal rat intestine: anastomosis to the normal bowel of the host.

We have examined the functional integrity of the transplanted fetal rat intestine following anastomosis of the transplant to the intestine of the host after successful allogeneic transplantation of fetal rat intestine into the peritoneal cavity of the host. In the syngeneic group all the 10 animals survived after end-to-side anastomosis. After end-to-end anastomosis 11 of 20 rats survived in the syngeneic group. In the allogeneic group we saw a marked host versus graft reaction (HVGR) after end-to-end anastomosis when treated orally with cyclosporin A in a dosage of 10 mg/kg per day. After administering the cyclosporin A parenterally, the survival rate in the allogeneic group after end-to-end anastomosis was 45%.