BACKGROUND: Several studies have demonstrated an increased risk of non-AIDS cancers in HIV patients and, for some cancers, also in relatives of HIV patients. We aimed to estimate (1) the risk of anal carcinoma among HIV patients and their parents, and (2) the mortality after a diagnosis of anal carcinoma. METHODS: We used Poisson regression to estimate the incidence rate ratios (IRR) of anal carcinoma in (1) a population of HIV patients identified from the Danish HIV Cohort Study (n = 4993) compared with a population control cohort matched on age and gender (n = 59,916) for the period 1995-2009, and (2) parents of HIV patients compared with parents of controls for the period 1978-2009. Cancer diagnoses were identified from The Danish Cancer Registry. We further estimated the mortality rate ratios (MRR) of HIV patients compared with controls after the diagnosis of anal carcinoma. RESULTS: Thirty-six HIV patients versus 8 population controls were diagnosed with anal carcinoma. HIV patients had an increased risk of anal carcinoma (IRR 77.9, 95% CI 36.2-167.7), especially among men who have sex with men (MSM) (IRR 101.4, 95% CI 39.3-261.5). Fathers of HIV patients had an increased risk of anal carcinoma (IRR 7.4, 95% CI 1.4-38.3) compared to fathers of population controls. Mortality after diagnosis of anal carcinoma was increased in male HIV patients compared with the male control cohort (MRR 3.2, 95% CI 1.1-9.2). CONCLUSIONS: Danish HIV patients, especially MSM, have a considerably increased risk of anal carcinoma. We cannot exclude that fathers of HIV patients have an increased risk of anal carcinoma.
BACKGROUND: Several studies have demonstrated an increased risk of non-AIDS cancers in HIVpatients and, for some cancers, also in relatives of HIVpatients. We aimed to estimate (1) the risk of anal carcinoma among HIVpatients and their parents, and (2) the mortality after a diagnosis of anal carcinoma. METHODS: We used Poisson regression to estimate the incidence rate ratios (IRR) of anal carcinoma in (1) a population of HIVpatients identified from the Danish HIV Cohort Study (n = 4993) compared with a population control cohort matched on age and gender (n = 59,916) for the period 1995-2009, and (2) parents of HIVpatients compared with parents of controls for the period 1978-2009. Cancer diagnoses were identified from The Danish Cancer Registry. We further estimated the mortality rate ratios (MRR) of HIVpatients compared with controls after the diagnosis of anal carcinoma. RESULTS: Thirty-six HIVpatients versus 8 population controls were diagnosed with anal carcinoma. HIVpatients had an increased risk of anal carcinoma (IRR 77.9, 95% CI 36.2-167.7), especially among men who have sex with men (MSM) (IRR 101.4, 95% CI 39.3-261.5). Fathers of HIVpatients had an increased risk of anal carcinoma (IRR 7.4, 95% CI 1.4-38.3) compared to fathers of population controls. Mortality after diagnosis of anal carcinoma was increased in male HIVpatients compared with the male control cohort (MRR 3.2, 95% CI 1.1-9.2). CONCLUSIONS: Danish HIVpatients, especially MSM, have a considerably increased risk of anal carcinoma. We cannot exclude that fathers of HIVpatients have an increased risk of anal carcinoma.
Authors: Fengyi Jin; Claire M Vajdic; Matthew Law; Janaki Amin; Marina van Leeuwen; Skye McGregor; I Mary Poynten; David J Templeton; Andrew E Grulich Journal: AIDS Date: 2019-07-01 Impact factor: 4.177
Authors: Julia L Marcus; Chun Chao; Wendy A Leyden; Lanfang Xu; Jeanette Yu; Michael A Horberg; Daniel Klein; William J Towner; Charles P Quesenberry; Donald I Abrams; Michael J Silverberg Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-02-24 Impact factor: 4.254
Authors: Cristovam Scapulatempo-Neto; Carlos Veo; José Humberto T G Fregnani; Adriana Lorenzi; Allini Mafra; Armando G F Melani; Edgar Antonio Alemán Loaiza; Luciana Albina Reis Rosa; Cristina Mendes de Oliveira; José Eduardo Levi; Adhemar Longatto-Filho Journal: Oncol Lett Date: 2017-01-25 Impact factor: 2.967
Authors: Emily A Burger; Michael A Dyer; Stephen Sy; Joel M Palefsky; Alexandra de Pokomandy; François Coutlee; Michael J Silverberg; Jane J Kim Journal: J Acquir Immune Defic Syndr Date: 2018-09-01 Impact factor: 3.731