BACKGROUND: Noninvasive laboratory tests have been widely used in the diagnosis of liver fibrosis. This study was designed to evaluate the diagnostic value of the four serum markers detected on a JETLIA-962 chemiluminescence analyzer and the FibroTest index for chronic hepatitis B (CHB) related liver fibrosis. METHODS: A JETLIA-962 chemiluminescence analyzer was used to measure the hyaluronic acid (HA), laminin (LN), procollagen III N-terminal peptide (PIIINP), and type IV collagen (CIV) contents in the sera of CHB patients and controls. RESULTS: In our research, it was found that serum HA, LN, PIIINP, and CIV concentrations and the FibroTest index were correlated with fibrosis stage. The FibroTest index had the largest area under the receiver operating characteristic (ROC) curve for fibrosis and cirrhosis (0.80 and 0.776, respectively). The five indices together were able to exclude fibrosis with a negative likelihood ratio <0.1. The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were separately established. CONCLUSIONS: We found that the JETLIA-962 chemiluminescence analyzer was of great value in diagnosis of liver fibrosis. Combining five indices improved the diagnostic efficiency and reduced the incidences of unnecessary liver biopsies. Two logistic regression equations established may be helpful in diagnosing liver fibrosis and early cirrhosis, which need to be further evaluated.
BACKGROUND: Noninvasive laboratory tests have been widely used in the diagnosis of liver fibrosis. This study was designed to evaluate the diagnostic value of the four serum markers detected on a JETLIA-962 chemiluminescence analyzer and the FibroTest index for chronic hepatitis B (CHB) related liver fibrosis. METHODS: A JETLIA-962 chemiluminescence analyzer was used to measure the hyaluronic acid (HA), laminin (LN), procollagen III N-terminal peptide (PIIINP), and type IV collagen (CIV) contents in the sera of CHB patients and controls. RESULTS: In our research, it was found that serum HA, LN, PIIINP, and CIV concentrations and the FibroTest index were correlated with fibrosis stage. The FibroTest index had the largest area under the receiver operating characteristic (ROC) curve for fibrosis and cirrhosis (0.80 and 0.776, respectively). The five indices together were able to exclude fibrosis with a negative likelihood ratio <0.1. The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were separately established. CONCLUSIONS: We found that the JETLIA-962 chemiluminescence analyzer was of great value in diagnosis of liver fibrosis. Combining five indices improved the diagnostic efficiency and reduced the incidences of unnecessary liver biopsies. Two logistic regression equations established may be helpful in diagnosing liver fibrosis and early cirrhosis, which need to be further evaluated.
Authors: Xavier Forns; Sergi Ampurdanès; Josep M Llovet; John Aponte; Llorenç Quintó; Eva Martínez-Bauer; Miquel Bruguera; Jose Maria Sánchez-Tapias; Juan Rodés Journal: Hepatology Date: 2002-10 Impact factor: 17.425
Authors: Alex Yui Hui; Henry Lik-Yuen Chan; Vincent Wai-Sun Wong; Choong-Tsek Liew; Angel Mei-Ling Chim; Francis Ka-Leung Chan; Joseph Jao-Yiu Sung Journal: Am J Gastroenterol Date: 2005-03 Impact factor: 10.864