BACKGROUND: As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer. METHODS: Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls. RESULTS: No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05). CONCLUSIONS: Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women. IMPACT: These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women.
BACKGROUND: As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer. METHODS: Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls. RESULTS: No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05). CONCLUSIONS:Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women. IMPACT: These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women.
Authors: Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio Journal: Proc Natl Acad Sci U S A Date: 2009-05-27 Impact factor: 11.205
Authors: Andrew D Johnson; Robert E Handsaker; Sara L Pulit; Marcia M Nizzari; Christopher J O'Donnell; Paul I W de Bakker Journal: Bioinformatics Date: 2008-10-30 Impact factor: 6.937
Authors: Xiao Ou Shu; Jirong Long; Qiuyin Cai; Lu Qi; Yong-Bing Xiang; Yoon Shin Cho; E Shyong Tai; Xiangyang Li; Xu Lin; Wong-Ho Chow; Min Jin Go; Mark Seielstad; Wei Bao; Huaixing Li; Marilyn C Cornelis; Kai Yu; Wanqing Wen; Jiajun Shi; Bok-Ghee Han; Xue Ling Sim; Liegang Liu; Qibin Qi; Hyung-Lae Kim; Daniel P K Ng; Jong-Young Lee; Young Jin Kim; Chun Li; Yu-Tang Gao; Wei Zheng; Frank B Hu Journal: PLoS Genet Date: 2010-09-16 Impact factor: 5.917
Authors: Margaret A Gates; Shelley S Tworoger; Kathryn L Terry; Immaculata De Vivo; David J Hunter; Susan E Hankinson; Daniel W Cramer Journal: Int J Cancer Date: 2009-02-01 Impact factor: 7.396
Authors: Honglin Song; Susan J Ramus; Susanne Krüger Kjaer; Richard A DiCioccio; Georgia Chenevix-Trench; Celeste Leigh Pearce; Estrid Hogdall; Alice S Whittemore; Valerie McGuire; Claus Hogdall; Jan Blaakaer; Anna H Wu; David J Van Den Berg; Daniel O Stram; Usha Menon; Aleksandra Gentry-Maharaj; Ian J Jacobs; Penny M Webb; Jonathan Beesley; Xiaoqing Chen; Mary Anne Rossing; Jennifer A Doherty; Jenny Chang-Claude; Shan Wang-Gohrke; Marc T Goodman; Galina Lurie; Pamela J Thompson; Michael E Carney; Roberta B Ness; Kirsten Moysich; Ellen L Goode; Robert A Vierkant; Julie M Cunningham; Stephanie Anderson; Joellen M Schildkraut; Andrew Berchuck; Edwin S Iversen; Patricia G Moorman; Montserrat Garcia-Closas; Stephen Chanock; Jolanta Lissowska; Louise Brinton; Hoda Anton-Culver; Argyrios Ziogas; Wendy R Brewster; Bruce A J Ponder; Douglas F Easton; Simon A Gayther; Paul D P Pharoah Journal: Hum Mol Genet Date: 2009-03-20 Impact factor: 6.150