BACKGROUND AND AIMS: Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC). METHODS: We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method. RESULTS: Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively. CONCLUSIONS: Serum L-FABP is used as a new diagnostic marker to detect liver injury.
BACKGROUND AND AIMS: Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC). METHODS: We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method. RESULTS:Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively. CONCLUSIONS: Serum L-FABP is used as a new diagnostic marker to detect liver injury.
Authors: Constantine J Karvellas; Jaime L Speiser; Mélanie Tremblay; William M Lee; Christopher F Rose Journal: Hepatology Date: 2017-01-19 Impact factor: 17.425
Authors: Gerd A Kullak-Ublick; Raul J Andrade; Michael Merz; Peter End; Andreas Benesic; Alexander L Gerbes; Guruprasad P Aithal Journal: Gut Date: 2017-03-23 Impact factor: 23.059
Authors: Maria Mikus; Kimi Drobin; Marcus Gry; Julie Bachmann; Johan Lindberg; Getnet Yimer; Eleni Aklillu; Eyasu Makonnen; Getachew Aderaye; James Roach; Ian Fier; Caroline Kampf; Jens Göpfert; Hugo Perazzo; Thierry Poynard; Camilla Stephens; Raúl J Andrade; M Isabel Lucena; Nadir Arber; Mathias Uhlén; Paul B Watkins; Jochen M Schwenk; Peter Nilsson; Ina Schuppe-Koistinen Journal: Liver Int Date: 2016-06-22 Impact factor: 5.828