| Literature DB >> 23290051 |
Eriko Kudo1, Manabu Taura, Kouki Matsuda, Masako Shimamoto, Ryusho Kariya, Hiroki Goto, Shinichiro Hattori, Shinya Kimura, Seiji Okada.
Abstract
The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection.Entities:
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Year: 2012 PMID： 23290051 DOI： 10.1016/j.bmcl.2012.12.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823