Literature DB >> 23287824

A simple base-mediated amidation of aldehydes with azides.

Sameer S Kulkarni1, Xiangdong Hu, Roman Manetsch.   

Abstract

A practical and efficient amidation reaction involving aromatic aldehydes and various azides under mild conditions is described. A broad spectrum of functional groups was tolerated, and the amides were synthesized in moderate to excellent yields, presenting an attractive alternative to the currently available synthetic methods.

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Year:  2013        PMID： 23287824     DOI： 10.1039/c2cc37289d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  N,N-diethylurea-catalyzed amidation between electron-deficient aryl azides and phenylacetaldehydes.

Authors:  Sheng Xie; Olof Ramström; Mingdi Yan
Journal:  Org Lett       Date:  2015-01-23       Impact factor: 6.005

2.  Selective Radical Amination of Aldehydic C(sp2)-H Bonds with Fluoroaryl Azides via Co(II)-Based Metalloradical Catalysis: Synthesis of N-Fluoroaryl Amides from Aldehydes under Neutral and Nonoxidative Conditions.

Authors:  Li-Mei Jin; Hongjian Lu; Yuan Cui; Christopher L Lizardi; Thiago N Arzua; Lukasz Wojtas; Xin Cui; X Peter Zhang
Journal:  Chem Sci       Date:  2014-06-01       Impact factor: 9.825

3.  Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Authors:  Milon Mondal; M Yagiz Unver; Asish Pal; Matthijs Bakker; Stephan P Berrier; Anna K H Hirsch
Journal:  Chemistry       Date:  2016-09-07       Impact factor: 5.236

4.  Base-catalyzed synthesis of aryl amides from aryl azides and aldehydes.

Authors:  Sheng Xie; Yang Zhang; Olof Ramström; Mingdi Yan
Journal:  Chem Sci       Date:  2015-10-22       Impact factor: 9.825
  4 in total

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