BACKGROUND: Streptococcus salivarius K12 has been shown to inhibit the growth of Streptococcus pyogenes due to bacteriocins release. Because of its ability to colonize the oral cavity, we have tested the strain K12 for its efficacy in preventing streptococcal pharyngitis and/or tonsillitis in adults. METHODS: Forty adults with a diagnosis of recurrent oral streptococcal pharyngitis were enrolled in the study. Twenty of these subjects took for 90 days a tablet containing Streptococcus salivarius K12 (Bactoblis®). The other 20 subjects served as untreated controls. A 6-month follow-up was included to evaluate any persistent protective role. RESULTS: The 20 adults who completed the 90-day course of Bactoblis® showed a reduction in their episodes of streptococcal pharyngeal infection (about 80%). The 90 days treatment was also associated with an approximately 60% reduction in the incidence of reported pharyngitis in the 6-month period following use of the product. The product was well tolerated by the subjects with no treatment-related side effects or drop-outs reported. CONCLUSION: Prophylactic administration of Streptococcus salivarius K12 to adults having a history of recurrent oral streptococcal pathology reduced the number of episodes of streptococcal pharyngeal infections and/or tonsillitis.
BACKGROUND:Streptococcus salivarius K12 has been shown to inhibit the growth of Streptococcus pyogenes due to bacteriocins release. Because of its ability to colonize the oral cavity, we have tested the strain K12 for its efficacy in preventing streptococcal pharyngitis and/or tonsillitis in adults. METHODS: Forty adults with a diagnosis of recurrent oral streptococcal pharyngitis were enrolled in the study. Twenty of these subjects took for 90 days a tablet containing Streptococcus salivarius K12 (Bactoblis®). The other 20 subjects served as untreated controls. A 6-month follow-up was included to evaluate any persistent protective role. RESULTS: The 20 adults who completed the 90-day course of Bactoblis® showed a reduction in their episodes of streptococcal pharyngeal infection (about 80%). The 90 days treatment was also associated with an approximately 60% reduction in the incidence of reported pharyngitis in the 6-month period following use of the product. The product was well tolerated by the subjects with no treatment-related side effects or drop-outs reported. CONCLUSION: Prophylactic administration of Streptococcus salivarius K12 to adults having a history of recurrent oral streptococcal pathology reduced the number of episodes of streptococcal pharyngeal infections and/or tonsillitis.
Authors: Jovanka Lukic; Vivien Chen; Ivana Strahinic; Jelena Begovic; Hadar Lev-Tov; Stephen C Davis; Marjana Tomic-Canic; Irena Pastar Journal: Wound Repair Regen Date: 2018-02-09 Impact factor: 3.617
Authors: M John; E M Dunne; P V Licciardi; C Satzke; O Wijburg; R M Robins-Browne; S O'Leary Journal: Eur J Clin Microbiol Infect Dis Date: 2013-03-20 Impact factor: 3.267
Authors: Francesco Di Pierro; Valeria Sagheddu; Serena Galletti; Mara Forti; Marina Elli; Alexander Bertuccioli; Simone Gaeta Journal: Front Microbiol Date: 2021-06-17 Impact factor: 5.640
Authors: Jeremy P Burton; Philip A Wescombe; Jean M Macklaim; Melissa H C Chai; Kyle Macdonald; John D F Hale; John Tagg; Gregor Reid; Gregory B Gloor; Peter A Cadieux Journal: PLoS One Date: 2013-06-13 Impact factor: 3.240