PURPOSE: In the present study, we assessed expression of neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal effluent (pNGAL) from peritoneal dialysis (PD) patients, and we evaluated factors that might affect its level in basal conditions. METHODS: Our cross-sectional study included all 69 patients on PD at our institution. We evaluated patient history, hydration status, residual renal function, indices of dialysis adequacy, peritoneal transport type, serum C-reactive protein, ferritin, serum NGAL (sNGAL) and pNGAL. Univariate and multivariate linear regression models were used to evaluate predictors of pNGAL. RESULTS: Of the study patients, 39 (56.5%) were men, and 54 (78.3%) were on continuous ambulatory PD. Median age in the group was 61 years [interquartile range (IQR): 46.5 - 71 years]. Median sNGAL was 487 ng/mL (IQR: 407 - 586 ng/mL), and median pNGAL was 35 ng/mL (IQR: 21 - 46 ng/mL). dNGAL correlated directly with weekly dialytic clearance of creatinine (ρ = 0.291, p = 0.02) and with sNGAL (ρ = 0.269, p = 0.031). The same variables were also independent predictors of pNGAL (β = 0.30 and 0.29 respectively, both p < 0.05) in multivariate analysis. CONCLUSIONS: In our analysis, basal levels of pNGAL were influenced by sNGAL and by dialytic clearance of creatinine.
PURPOSE: In the present study, we assessed expression of neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal effluent (pNGAL) from peritoneal dialysis (PD) patients, and we evaluated factors that might affect its level in basal conditions. METHODS: Our cross-sectional study included all 69 patients on PD at our institution. We evaluated patient history, hydration status, residual renal function, indices of dialysis adequacy, peritoneal transport type, serum C-reactive protein, ferritin, serum NGAL (sNGAL) and pNGAL. Univariate and multivariate linear regression models were used to evaluate predictors of pNGAL. RESULTS: Of the study patients, 39 (56.5%) were men, and 54 (78.3%) were on continuous ambulatory PD. Median age in the group was 61 years [interquartile range (IQR): 46.5 - 71 years]. Median sNGAL was 487 ng/mL (IQR: 407 - 586 ng/mL), and median pNGAL was 35 ng/mL (IQR: 21 - 46 ng/mL). dNGAL correlated directly with weekly dialytic clearance of creatinine (ρ = 0.291, p = 0.02) and with sNGAL (ρ = 0.269, p = 0.031). The same variables were also independent predictors of pNGAL (β = 0.30 and 0.29 respectively, both p < 0.05) in multivariate analysis. CONCLUSIONS: In our analysis, basal levels of pNGAL were influenced by sNGAL and by dialytic clearance of creatinine.
Authors: Joseph C K Leung; Man Fai Lam; Sydney C W Tang; Loretta Y Y Chan; K Y Tam; Terence P S Yip; Kar Neng Lai Journal: J Clin Immunol Date: 2009-01-16 Impact factor: 8.317
Authors: Guanhu Bao; Matthew Clifton; Trisha M Hoette; Kiyoshi Mori; Shi-Xian Deng; Andong Qiu; Melanie Viltard; David Williams; Neal Paragas; Thomas Leete; Ritwij Kulkarni; Xiangpo Li; Belinda Lee; Avtandil Kalandadze; Adam J Ratner; Juan Carlos Pizarro; Kai M Schmidt-Ott; Donald W Landry; Kenneth N Raymond; Roland K Strong; Jonathan Barasch Journal: Nat Chem Biol Date: 2010-06-27 Impact factor: 15.040
Authors: Jolanta Malyszko; Jacek S Malyszko; Ewa Koc-Zorawska; Piotr Kozminski; Michal Mysliwiec Journal: Kidney Blood Press Res Date: 2009 Impact factor: 2.687
Authors: Neha Dhingra Pottanat; Amy C Brook; Maria Bartosova; Hanna Cortado; Sudipti Gupta; Birong Li; Ashley R Jackson; Martin Vonau; Shira Cohen; Maria Ferrara; Christina B Ching; John David Spencer; Annelie Brauner; Donald J Fraser; Claus Peter Schmitt; Matthias Eberl; Rose Ayoob; Brian Becknell Journal: Sci Rep Date: 2019-05-23 Impact factor: 4.379