Literature DB >> 23283758

Differential Response to Methylphenidate in Inattentive and Combined Subtype ADHD.

Susan H Beery1, Herbert C Quay2, William E Pelham3.   

Abstract

OBJECTIVE: To examine response to methylphenidate (MPH) assessed by direct observation of ecologically valid behaviors in boys with ADHD with high hyperactivity-impulsivity (HI) and those with predominantly inattentive symptoms (ADHD/I).
METHOD: Sixty-three boys ages 7 to 13 participated in an ADHD Summer Treatment Program and received a double-blind placebo-controlled assessment of .3 mg/kg of MPH on problem behaviors and individualized behavior goals. Medication effect sizes were calculated for each child for each behavior.
RESULTS: Children with ADHD/HI ( n = 21) displayed larger MPH effect sizes for interrupting, verbal abuse, and compliance, and marginally greater response for teasing and counselor-directed goals. Children with ADHD/I ( n = 21) displayed small medication effect sizes ( ds < .20) for many behaviors often identified as primary deficits in this group (e.g., attention to activities, peer interaction, class work completion, and accuracy).
CONCLUSION: Systematic medication assessment for ADHD/I that quantifies response in ecologically valid areas of functional impairment is essential.

Entities:  

Keywords:  ADHD subtypes; medication treatment; methylphenidate

Mesh:

Substances:

Year:  2016        PMID: 23283758     DOI: 10.1177/1087054712469256

Source DB:  PubMed          Journal:  J Atten Disord        ISSN: 1087-0547            Impact factor:   3.256


  5 in total

1.  Neurocognitive Profile of Children with Attention Deficit Hyperactivity Disorders (ADHD): A comparison between subtypes.

Authors:  Nastaran Ahmadi; Mohammad Reza Mohammadi; Seyed Mohsen Araghi; Hadi Zarafshan
Journal:  Iran J Psychiatry       Date:  2014-10

Review 2.  Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies.

Authors:  Ike C de la Peña; Michael C Pan; Chau Giang Thai; Tamara Alisso
Journal:  Brain Sci       Date:  2020-05-14

3.  A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study.

Authors:  Tor-Arne Hegvik; Kaya Kvarme Jacobsen; Mats Fredriksen; Tetyana Zayats; Jan Haavik
Journal:  J Neural Transm (Vienna)       Date:  2016-04-18       Impact factor: 3.575

4.  Clinical and Neuropsychological Predictors of Methylphenidate Response in Children and Adolescents with ADHD: A Naturalistic Follow-up Study in a Spanish Sample.

Authors:  María Vallejo-Valdivielso; Pilar de Castro-Manglano; Azucena Díez-Suárez; Juan J Marín-Méndez; Cesar A Soutullo
Journal:  Clin Pract Epidemiol Ment Health       Date:  2019-12-31

5.  Pharmacotherapy of ADHD in Adults With Autism Spectrum Disorder: Effectiveness and Side Effects.

Authors:  J J Muit; N Bothof; C C Kan
Journal:  J Atten Disord       Date:  2019-10-18       Impact factor: 3.256

  5 in total

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