Literature DB >> 23283615

Walking unsteadily: a case of acute cerebellar ataxia.

Federico Simonetta1, Fotini Christou, Riccardo E Vandoni, Thomas Nierle.   

Abstract

Acute cerebellar ataxia is an infrequent neurological syndrome in adults especially if complicated by additional neurological deficits. We report the case of a 69-year-old woman who presented with sudden onset of left facial droop, dizziness, slurred speech and impaired balance. Her medical history included paroxysmal atrial fibrillation and a sigmoid diverticular abscess treated with ciprofloxacin and metronidazole. Cranial computed tomographic angiography and MRI showed no signs of acute ischaemia or haemorrhage but demonstrated symmetrically distributed lesions in the cerebellar dentate nuclei. A diagnosis of metronidazole-induced encephalopathy was suspected. Metronidazole was stopped and the patient completely recovered. Metronidazole is a commonly prescribed medication. Clinicians should be aware of the clinical and radiological presentation of metronidazole-induced encephalopathy so that this serious but completely reversible condition can be promptly diagnosed.

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Year:  2013        PMID: 23283615      PMCID: PMC3604282          DOI: 10.1136/bcr-2012-007688

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  16 in total

1.  Reversible metronidazole-induced lesions of the cerebellar dentate nuclei.

Authors:  Bryan K Woodruff; Eelco F M Wijdicks; William F Marshall
Journal:  N Engl J Med       Date:  2002-01-03       Impact factor: 91.245

2.  Wernicke's encephalopathy: atypical manifestation at MR imaging.

Authors:  S J Bae; H K Lee; J H Lee; C G Choi; D C Suh
Journal:  AJNR Am J Neuroradiol       Date:  2001-09       Impact factor: 3.825

3.  Metronidazole neuropathy.

Authors:  W G Bradley; I J Karlsson; C G Rassol
Journal:  Br Med J       Date:  1977-09-03

4.  Side effects of metronidazole.

Authors:  A J Giannini
Journal:  Am J Psychiatry       Date:  1977-03       Impact factor: 18.112

5.  Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy.

Authors:  A Ahmed; D J Loes; E L Bressler
Journal:  Neurology       Date:  1995-03       Impact factor: 9.910

6.  Neurologic toxicity associated with high-dose metronidazole therapy.

Authors:  S Frytak; C H Moertel; D S Childs
Journal:  Ann Intern Med       Date:  1978-03       Impact factor: 25.391

7.  Central nervous system toxicity associated with metronidazole therapy.

Authors:  R K Kusumi; J F Plouffe; R H Wyatt; R J Fass
Journal:  Ann Intern Med       Date:  1980-07       Impact factor: 25.391

8.  Metronidazole-induced encephalopathy and inferior olivary hypertrophy: lesion analysis with diffusion-weighted imaging and apparent diffusion coefficient maps.

Authors:  Jung Im Seok; Hanseung Yi; Young Min Song; Won Yong Lee
Journal:  Arch Neurol       Date:  2003-12

9.  Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs.

Authors:  D N Rao; R P Mason
Journal:  J Biol Chem       Date:  1987-08-25       Impact factor: 5.157

10.  MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity.

Authors:  Conor J Heaney; Norbert G Campeau; E Paul Lindell
Journal:  AJNR Am J Neuroradiol       Date:  2003-09       Impact factor: 3.825

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  4 in total

Review 1.  Drug-induced cerebellar ataxia: a systematic review.

Authors:  J van Gaalen; F G Kerstens; R P P W M Maas; L Härmark; B P C van de Warrenburg
Journal:  CNS Drugs       Date:  2014-12       Impact factor: 5.749

2.  An 82-year-old man with ataxia and dysarthria.

Authors:  Lilian L Y Vivas; Wayne L Gold; Daniel M Mandell; Peter E Wu
Journal:  CMAJ       Date:  2015-10-13       Impact factor: 8.262

3.  Metronidazole-induced encephalopathy: a systematic review.

Authors:  Caspar Godthaab Sørensen; William Kristian Karlsson; Faisal Mohammad Amin; Mette Lindelof
Journal:  J Neurol       Date:  2018-12-07       Impact factor: 4.849

Review 4.  The neuropathology of the adult cerebellum.

Authors:  Arnulf H Koeppen
Journal:  Handb Clin Neurol       Date:  2018
  4 in total

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