| Literature DB >> 23283516 |
Susanne Sattler1, Hermelijn H Smits, Damo Xu, Fang-Ping Huang.
Abstract
Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.Entities:
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Year: 2013 PMID： 23283516 DOI： 10.1007/s00005-012-0208-8
Source DB: PubMed Journal: Arch Immunol Ther Exp (Warsz) ISSN： 0004-069X Impact factor: 4.291