BACKGROUND: The response to dietary fat plays a key role in metabolic health. Although this can vary widely between individuals, variation within an individual and the associated contribution of phenotypic and genotypic factors to this variation are less defined. OBJECTIVES: The objectives were to quantify within-person variation in triacylglycerol response by means of a novel variation score (S(v)) and to explore the phenotypic and genotypic factors associated with this score. DESIGN: Two consecutive 5-h oral-lipid-tolerance tests (OLTTs) were conducted in 51 healthy adults aged 18-60 y with a BMI (in kg/m²) of 18.5 to 49.8. Detailed body composition, physical function, biochemistry, and genotype data were gathered. RESULTS: The postprandial triacylglycerol response profile did not differ (P = 0.64) across OLTTs for the group; nor did average concentrations of functional markers apolipoprotein C2 (P = 0.73) and apolipoprotein C3 (P = 0.74). S(v) was low in most (82%) of the adults and was significantly (P < 0.05) associated with age, fasting triacylglycerol, triacylglycerol AUC, and fasting nonessential fatty acids. Significant associations were also observed between S(v) and single nucleotide polymorphisms in 7 genes (APOA1, IL1α, IL1β, TLR4, TCF7L2, CCK1Rec, and STAT3) after correction for phenotypic differences. CONCLUSIONS: This work showed that the within-person variability in postprandial lipemic response is low in most healthy adults. It also showed that variability in this response is associated with a defined set of phenotypic and genotypic characteristics.
RCT Entities:
BACKGROUND: The response to dietary fat plays a key role in metabolic health. Although this can vary widely between individuals, variation within an individual and the associated contribution of phenotypic and genotypic factors to this variation are less defined. OBJECTIVES: The objectives were to quantify within-person variation in triacylglycerol response by means of a novel variation score (S(v)) and to explore the phenotypic and genotypic factors associated with this score. DESIGN: Two consecutive 5-h oral-lipid-tolerance tests (OLTTs) were conducted in 51 healthy adults aged 18-60 y with a BMI (in kg/m²) of 18.5 to 49.8. Detailed body composition, physical function, biochemistry, and genotype data were gathered. RESULTS: The postprandial triacylglycerol response profile did not differ (P = 0.64) across OLTTs for the group; nor did average concentrations of functional markers apolipoprotein C2 (P = 0.73) and apolipoprotein C3 (P = 0.74). S(v) was low in most (82%) of the adults and was significantly (P < 0.05) associated with age, fasting triacylglycerol, triacylglycerol AUC, and fasting nonessential fatty acids. Significant associations were also observed between S(v) and single nucleotide polymorphisms in 7 genes (APOA1, IL1α, IL1β, TLR4, TCF7L2, CCK1Rec, and STAT3) after correction for phenotypic differences. CONCLUSIONS: This work showed that the within-person variability in postprandial lipemic response is low in most healthy adults. It also showed that variability in this response is associated with a defined set of phenotypic and genotypic characteristics.
Authors: Kathryn J Burton-Pimentel; Grégory Pimentel; Maria Hughes; Charlotte Cjr Michielsen; Attia Fatima; Nathalie Vionnet; Lydia A Afman; Helen M Roche; Lorraine Brennan; Mark Ibberson; Guy Vergères Journal: Mol Nutr Food Res Date: 2021-01-29 Impact factor: 5.914
Authors: Ciara Morris; Colm M O'Grada; Miriam F Ryan; Michael J Gibney; Helen M Roche; Eileen R Gibney; Lorraine Brennan Journal: Lipids Health Dis Date: 2015-07-01 Impact factor: 3.876
Authors: Aoife M Curran; Miriam F Ryan; Elaine Drummond; Eileen R Gibney; Michael J Gibney; Helen M Roche; Lorraine Brennan Journal: PLoS One Date: 2016-08-18 Impact factor: 3.240
Authors: Aoibheann M McMorrow; Ruth M Connaughton; Tiago R Magalhães; Fiona C McGillicuddy; Maria F Hughes; David Cheishvili; Melissa J Morine; Sean Ennis; Marie-Louise Healy; Edna F Roche; Richard E Tremblay; Moshe Szyf; Fiona E Lithander; Helen M Roche Journal: Mol Nutr Food Res Date: 2018-05 Impact factor: 5.914
Authors: Aoife M Curran; Marie Pier Scott-Boyer; Jim Kaput; Miriam F Ryan; Elaine Drummond; Eileen R Gibney; Michael J Gibney; Helen M Roche; Lorraine Brennan Journal: PLoS One Date: 2018-08-30 Impact factor: 3.240