Literature DB >> 23282775

Positive tuberculin test and risk of infection by Mycobacterium tuberculosis in a tuberculosis clinic settled in an upright building, in Minas Gerais, Brazil.

Silvana Spíndola De Miranda1, Alice Campos De Oliveira, Aline Xavier Santos, Deborah Pereira Prado, Cláudia Leão Soares, Rachel Santos Nery, Henriquez Cunha Vieira, Wânia Da Silva Carvalho.   

Abstract

BACKGROUND: Occupational Tuberculosis (TB) can lead to work absenteeism and a negative professional impact. Knowing the reactivity of the tuberculin test and the risk of M. tuberculosis infection among healthcare professionals is essential for the revision and reinforcement of control measures against TB transmission. AIM: To assess the reactivity of tuberculin test and risk of M. tuberculosis infection among healthcare professionals working in an upright building, in which a TB Reference Clinic is placed. SUBJECTS AND METHODS: A tuberculosis Skin Test (TST) was done to 251 staff members of a TB clinic that did not have a previous history or suspicion of TB and that did not have a previous TST done. Among subjects with absence of reaction, repeated tests were carried out to assess booster reaction.
RESULTS: Fifty one percent of studied subjects (129) had a positive tuberculin test. The booster phenomenon was evidenced in 35.7% (68/190). The seroconversion among non-reactive subjects, subjected to a new TST after one year, was 5.1%. The infection risk was 1.4.
CONCLUSIONS: This study indicates an important occupational risk of infection in healthcare settings exposed to high TB incidence, and should be used to better allocate resources for infection control.

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Year:  2012        PMID: 23282775     DOI: 10.4067/S0034-98872012000800008

Source DB:  PubMed          Journal:  Rev Med Chil        ISSN: 0034-9887            Impact factor:   0.553


  4 in total

1.  T Cell Activation and Proinflammatory Cytokine Production in Clinically Cured Tuberculosis Are Time-Dependent and Accompanied by Upregulation of IL-10.

Authors:  Marcos Vinícius da Silva; Amanda A Figueiredo; Juliana R Machado; Lúcio C Castellano; Patricia B D Alexandre; Rafael F Oliveira; Gladstone E L Faria; Sanívia A L Pereira; Denise B R Rodrigues; Virmondes Rodrigues
Journal:  PLoS One       Date:  2013-06-18       Impact factor: 3.240

2.  Expression pattern of transcription factors and intracellular cytokines reveals that clinically cured tuberculosis is accompanied by an increase in Mycobacterium-specific Th1, Th2, and Th17 cells.

Authors:  Marcos V da Silva; Vladimir J Massaro Junior; Juliana R Machado; Djalma A A Silva; Lúcio R Castellano; Patricia B D Alexandre; Denise B R Rodrigues; Virmondes Rodrigues
Journal:  Biomed Res Int       Date:  2015-04-27       Impact factor: 3.411

Review 3.  Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries: A Systematic Review and Meta-Analysis.

Authors:  Sharifa Nasreen; Mostafa Shokoohi; Monali S Malvankar-Mehta
Journal:  PLoS One       Date:  2016-10-06       Impact factor: 3.240

4.  Indicators to assess the quality of programs to prevent occupational risk for tuberculosis: are they feasible?

Authors:  Talita Raquel Dos Santos; Maria Clara Padoveze; Lúcia Yasuko Izumi Nichiata; Renata Ferreira Takahashi; Suely Itsuko Ciosak; Anna Luiza de Fátima Pinho Lins Gryschek
Journal:  Rev Lat Am Enfermagem       Date:  2016-06-07
  4 in total

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