Literature DB >> 23280931

Modular 'click-in-emulsion' bone-targeted nanogels.

Daniel A Heller1, Yair Levi, Jeisa M Pelet, Joshua C Doloff, Jasmine Wallas, George W Pratt, Shan Jiang, Gaurav Sahay, Avi Schroeder, Josh E Schroeder, Yieu Chyan, Christopher Zurenko, William Querbes, Miguel Manzano, Daniel S Kohane, Robert Langer, Daniel G Anderson.   

Abstract

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Year:  2012        PMID： 23280931      PMCID： PMC3815631          DOI： 10.1002/adma.201202881

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  27 in total

Review 1.  Bisphosphonates in osteoporosis.

Authors:  H Fleisch
Journal:  Eur Spine J       Date:  2003-09-16       Impact factor: 3.134

Review 2.  Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells.

Authors:  Serguei V Vinogradov; Tatiana K Bronich; Alexander V Kabanov
Journal:  Adv Drug Deliv Rev       Date:  2002-01-17       Impact factor: 15.470

3.  In vitro and in vivo characteristics of core-shell type nanogel particles: optimization of core cross-linking density and surface poly(ethylene glycol) density in PEGylated nanogels.

Authors:  Masato Tamura; Satoshi Ichinohe; Atsushi Tamura; Yutaka Ikeda; Yukio Nagasaki
Journal:  Acta Biomater       Date:  2011-05-27       Impact factor: 8.947

4.  Perfluorocarbon-loaded Shell Crosslinked Knedel-like Nanoparticles: Lessons regarding polymer mobility and self assembly.

Authors:  Andreas M Nyström; Jeremy W Bartels; Wenjun Du; Karen L Wooley
Journal:  J Polym Sci A Polym Chem       Date:  2009-02-12       Impact factor: 2.702

5.  Bisphosphonate conjugation to proteins as a means to impart bone affinity.

Authors:  H Uludag; N Kousinioris; T Gao; D Kantoci
Journal:  Biotechnol Prog       Date:  2000 Mar-Apr

6.  Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro.

Authors:  M F Moreau; C Guillet; P Massin; S Chevalier; H Gascan; M F Baslé; D Chappard
Journal:  Biochem Pharmacol       Date:  2006-11-03       Impact factor: 5.858

7.  Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization.

Authors:  Sidi A Bencherif; Daniel J Siegwart; Abiraman Srinivasan; Ferenc Horkay; Jeffrey O Hollinger; Newell R Washburn; Krzysztof Matyjaszewski
Journal:  Biomaterials       Date:  2009-07-09       Impact factor: 12.479

8.  Differences between bisphosphonates in binding affinities for hydroxyapatite.

Authors:  M A Lawson; Z Xia; B L Barnett; J T Triffitt; R J Phipps; J E Dunford; R M Locklin; F H Ebetino; R G G Russell
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2010-01       Impact factor: 3.368

9.  Enhanced core hydrophobicity, functionalization and cell penetration of polybasic nanomatrices.

Authors:  Omar Z Fisher; Timothy Kim; Stephen R Dietz; Nicholas A Peppas
Journal:  Pharm Res       Date:  2008-08-28       Impact factor: 4.200

Review 10.  Myeloid C-type lectins in innate immunity.

Authors:  Matthew J Robinson; David Sancho; Emma C Slack; Salomé LeibundGut-Landmann; Caetano Reis e Sousa
Journal:  Nat Immunol       Date:  2006-12       Impact factor: 25.606
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  8 in total

1.  Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules.

Authors:  Yingkai Liang; Kristi L Kiick
Journal:  Biomacromolecules       Date:  2016-01-25       Impact factor: 6.988

2.  Osteotropic therapy via targeted layer-by-layer nanoparticles.

Authors:  Stephen W Morton; Nisarg J Shah; Mohiuddin A Quadir; Zhou J Deng; Zhiyong Poon; Paula T Hammond
Journal:  Adv Healthc Mater       Date:  2013-10-09       Impact factor: 9.933

3.  Click chemistry plays a dual role in biodegradable polymer design.

Authors:  Jinshan Guo; Zhiwei Xie; Richard T Tran; Denghui Xie; Dadi Jin; Xiaochun Bai; Jian Yang
Journal:  Adv Mater       Date:  2013-12-23       Impact factor: 30.849

4.  Targeted drug delivery strategies for precision medicines.

Authors:  Mandana T Manzari; Yosi Shamay; Hiroto Kiguchi; Neal Rosen; Maurizio Scaltriti; Daniel A Heller
Journal:  Nat Rev Mater       Date:  2021-02-02       Impact factor: 66.308

5.  Strong Inhibition of Cholera Toxin B Subunit by Affordable, Polymer-Based Multivalent Inhibitors.

Authors:  Diksha Haksar; Eyleen de Poel; Linda Quarles van Ufford; Sumati Bhatia; Rainer Haag; Jeffrey Beekman; Roland J Pieters
Journal:  Bioconjug Chem       Date:  2019-01-24       Impact factor: 4.774

6.  Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.

Authors:  Teresa L Rapp; Yanfei Wang; Maegan A Delessio; Michael R Gau; Ivan J Dmochowski
Journal:  RSC Adv       Date:  2019-02-08       Impact factor: 4.036

Review 7.  Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles.

Authors:  Atena Abed; Maryam Derakhshan; Merat Karimi; Matin Shirazinia; Maryam Mahjoubin-Tehran; Mina Homayonfal; Michael R Hamblin; Seyed Abbas Mirzaei; Hamidreza Soleimanpour; Sadegh Dehghani; Farnaz Farzaneh Dehkordi; Hamed Mirzaei
Journal:  Front Pharmacol       Date:  2022-02-23       Impact factor: 5.810

8.  Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography.

Authors:  Simin Zuo; Wa'el Al Rawashdeh; Stefanie Rosenhain; Zuzanna Magnuska; Yamoah Grace Gyamfuah; Fabian Kiessling; Felix Gremse
Journal:  Mol Imaging Biol       Date:  2021-07-06       Impact factor: 3.488
  8 in total

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