| Literature DB >> 23279867 |
Adriano Olímpio da Silva1, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima.
Abstract
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC(50) of 7.8 μM.Entities:
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Year: 2012 PMID： 23279867 DOI： 10.1016/j.ejmech.2012.11.034
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514