Literature DB >> 23278111

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.

N Orr1, E W Hill, J Gu, P Govindarajan, J Conroy, E M van Grevenhof, B J Ducro, J A M van Arendonk, J H Knaap, P R van Weeren, D E Machugh, S Ennis, P A J Brama.   

Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).
© 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.

Entities:  

Keywords:  Equus caballus; Orthopaedic disease; SNP

Mesh：

Year:  2012        PMID： 23278111     DOI： 10.1111/age.12016

Source DB:  PubMed          Journal:  Anim Genet        ISSN： 0268-9146            Impact factor:   3.169


  5 in total

1.  Polymorphisms in ten candidate genes are associated with conformational and locomotive traits in Spanish Purebred horses.

Authors:  Natalia Sevane; Susana Dunner; Ana Boado; Javier Cañon
Journal:  J Appl Genet       Date:  2016-12-05       Impact factor: 3.240

Review 2.  Emerging genetic basis of osteochondritis dissecans.

Authors:  J Tyler Bates; John C Jacobs; Kevin G Shea; Julia Thom Oxford
Journal:  Clin Sports Med       Date:  2014-01-10       Impact factor: 2.182

3.  Identification and validation of risk loci for osteochondrosis in standardbreds.

Authors:  Annette M McCoy; Samantha K Beeson; Rebecca K Splan; Sigrid Lykkjen; Sarah L Ralston; James R Mickelson; Molly E McCue
Journal:  BMC Genomics       Date:  2016-01-12       Impact factor: 3.969

4.  Differences between horse selection based on two forms of osteochondrosis in fetlock.

Authors:  D Lewczuk; A Bereznowski; M Hecold; M Frąszczak; A Ruść; A Korwin-Kossakowska; J Szyda; S Kamiński
Journal:  J Appl Genet       Date:  2018-03-09       Impact factor: 3.240

Review 5.  Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.

Authors:  T Raudsepp; C J Finno; R R Bellone; J L Petersen
Journal:  Anim Genet       Date:  2019-09-30       Impact factor: 3.169
  5 in total

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