Literature DB >> 2327755

Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do.

K Riesbeck1, A Bredberg, A Forsgren.   

Abstract

At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not.

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Year:  1990        PMID： 2327755      PMCID： PMC171543          DOI： 10.1128/AAC.34.1.167

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes.

Authors:  L L Shen; W E Kohlbrenner; D Weigl; J Baranowski
Journal:  J Biol Chem       Date:  1989-02-15       Impact factor: 5.157

2.  Effect of doxycycline on immune response in mice.

Authors:  A Bellahsene; A Forsgren
Journal:  Infect Immun       Date:  1985-05       Impact factor: 3.441

3.  Amino acid incorporation by isolated rat liver mitochondria into two protein components of mitochondrial ATPase complex. Lack of incorporation into dicyclohexylcarbodiimide binding proteolipid.

Authors:  S Kuzela; K Luciaková; J Lakota
Journal:  FEBS Lett       Date:  1980-06-02       Impact factor: 4.124

4.  A procedure for the rapid preparation of mitochondria from rat liver.

Authors:  P H Reinhart; W M Taylor; F L Bygrave
Journal:  Biochem J       Date:  1982-06-15       Impact factor: 3.857

5.  Inhibition of Micrococcus luteus DNA gyrase by norfloxacin and 10 other quinolone carboxylic acids.

Authors:  M M Zweerink; A Edison
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

6.  Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts.

Authors:  P Hussy; G Maass; B Tümmler; F Grosse; U Schomburg
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191

7.  Fluorinated 4-quinolones induce hyperproduction of interleukin 2.

Authors:  K Riesbeck; J Andersson; M Gullberg; A Forsgren
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

8.  Interleukin-1 production by antibiotic-treated human monocytes.

Authors:  Y Roche; M Fay; M A Gougerot-Pocidalo
Journal:  J Antimicrob Chemother       Date:  1988-05       Impact factor: 5.790

9.  4-Quinolone antibiotics: positive genotoxic screening tests despite an apparent lack of mutation induction.

Authors:  A Bredberg; M Brant; K Riesbeck; Y Azou; A Forsgren
Journal:  Mutat Res       Date:  1989-03       Impact factor: 2.433

Review 10.  Antibacterial drugs and their interference with the biogenesis of mitochondria in animal and human cells.

Authors:  A M Kroon; C Van den Bogert
Journal:  Pharm Weekbl Sci       Date:  1983-06-24
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  23 in total

1.  Survival in critical illness is associated with early activation of mitochondrial biogenesis.

Authors:  Jane E Carré; Jean-Christophe Orban; Lorenza Re; Karen Felsmann; Wiebke Iffert; Michael Bauer; Hagir B Suliman; Claude A Piantadosi; Terry M Mayhew; Patrick Breen; Martin Stotz; Mervyn Singer
Journal:  Am J Respir Crit Care Med       Date:  2010-06-10       Impact factor: 21.405

2.  Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin.

Authors:  K Riesbeck; A Forsgren
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-06       Impact factor: 3.267

3.  Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines.

Authors:  N Duewelhenke; O Krut; P Eysel
Journal:  Antimicrob Agents Chemother       Date:  2006-11-06       Impact factor: 5.191

4.  Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones.

Authors:  E E McKee; M Ferguson; A T Bentley; T A Marks
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

5.  Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

Authors:  Kenichi Shimada; Timothy R Crother; Justin Karlin; Jargalsaikhan Dagvadorj; Norika Chiba; Shuang Chen; V Krishnan Ramanujan; Andrea J Wolf; Laurent Vergnes; David M Ojcius; Altan Rentsendorj; Mario Vargas; Candace Guerrero; Yinsheng Wang; Katherine A Fitzgerald; David M Underhill; Terrence Town; Moshe Arditi
Journal:  Immunity       Date:  2012-02-16       Impact factor: 31.745

Review 6.  Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components.

Authors:  Alison E Barnhill; Matt T Brewer; Steve A Carlson
Journal:  Antimicrob Agents Chemother       Date:  2012-05-21       Impact factor: 5.191

7.  A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.

Authors:  Amita Gupta; Aye Ökesli-Armlovich; David Morgens; Michael C Bassik; Chaitan Khosla
Journal:  J Biol Chem       Date:  2020-01-08       Impact factor: 5.157

8.  Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents.

Authors:  G Hayem; P X Petit; M Levacher; C Gaudin; M F Kahn; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

Review 9.  Is MOF an outcome parameter or a transient, adaptive state in critical illness?

Authors:  Nicolas Mongardon; Alex Dyson; Mervyn Singer
Journal:  Curr Opin Crit Care       Date:  2009-10       Impact factor: 3.687

10.  Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil.

Authors:  Leonidas A Bourikas; George Kolios; Vassilis Valatas; George Notas; Ioannis Drygiannakis; Iordanis Pelagiadis; Pinelopi Manousou; Stefanos Klironomos; Ioannis A Mouzas; Elias Kouroumalis
Journal:  Br J Pharmacol       Date:  2009-04-09       Impact factor: 8.739
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