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Literature DB >> 23277028

Tissue-specific implications of mitochondrial alterations in aging.

Danhui Liu¹, Hongzhi Li, Jianxin Lu, Yidong Bai.

Abstract

Aging is a multifactorial process during which physiological alterations occur in all tissues. A decline in mitochondrial function plays an important role in the process of aging and in aging-associated diseases. The mitochondrial genome encodes 13 essential subunits of protein complexes belonging to the oxidative phosphorylation system, while most of the mitochondria-related genes are encoded by the nuclear genome. Coordination between the nucleus and mitochondria is crucial for the regulation of mitochondrial biogenesis and function. In this review, we will discuss aging-related mitochondrial dysfunction in various tissues and its implication in aging-related diseases and the aging process.

Entities: Chemical

Mesh：

Year: 2013 PMID： 23277028 PMCID： PMC4706150 DOI： 10.2741/e654

Source DB: PubMed Journal: Front Biosci (Elite Ed) ISSN： 1945-0494

126 in total

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Journal: Neuromuscul Disord Date: 2002-06 Impact factor: 4.296

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8. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.

Authors: Julio J Ochoa; Reinald Pamplona; M Carmen Ramirez-Tortosa; Sergio Granados-Principal; Patricia Perez-Lopez; Alba Naudí; Manuel Portero-Otin; Magdalena López-Frías; Maurizio Battino; José L Quiles
Journal: Free Radic Biol Med Date: 2011-02-16 Impact factor: 7.376

Tissue-specific implications of mitochondrial alterations in aging.

1. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function.

2. Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement.

3. The mtDNA A8344G "MERRF" mutation is not a common cause of sporadic Parkinson disease in Italian population.

4. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing.

5. Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors.

6. The biologic clock: the mitochondria?

7. Early detection of Alzheimer's disease: a statistical approach using positron emission tomographic data.

8. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.

9. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation.

Review 10. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.

1. The Complicated Nature of Somatic mtDNA Mutations in Aging.

Review 2. The future of osteoarthritis therapeutics: targeted pharmacological therapy.