Lan Zhang1, Benrui Lin. 1. Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, P.R. China.
Abstract
BACKGROUND: Recent evidences suggest that oxidative stress is involved in the mechanism of chronic pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of our study is to investigate whether serum PON1 activity is associated with the presence of CP. METHODS: A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in this study. Serum PON1 activity was measured using paraoxon as a substrate. RESULTS: Serum PON1 activity was significantly decreased in CP patients compared with healthy subjects. Multivariable logistic regression analysis revealed that serum PON1 activity was a determinant of the presence of CP (OR = 0.992, 95% CI = 0.987-0.998; P = 0.006). CONCLUSIONS: Decreased serum PON1 activity may be considered as a predicting marker of the presence of CP.
BACKGROUND: Recent evidences suggest that oxidative stress is involved in the mechanism of chronic pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of our study is to investigate whether serum PON1 activity is associated with the presence of CP. METHODS: A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in this study. Serum PON1 activity was measured using paraoxon as a substrate. RESULTS: Serum PON1 activity was significantly decreased in CP patients compared with healthy subjects. Multivariable logistic regression analysis revealed that serum PON1 activity was a determinant of the presence of CP (OR = 0.992, 95% CI = 0.987-0.998; P = 0.006). CONCLUSIONS: Decreased serum PON1 activity may be considered as a predicting marker of the presence of CP.
Authors: Zobeida Cruz-Monserrate; Kristyn Gumpper; Valentina Pita; Phil A Hart; Christopher Forsmark; David C Whitcomb; Dhiraj Yadav; Richard T Waldron; Stephen Pandol; Hanno Steen; Vincent Anani; Natasha Kanwar; Santhi Swaroop Vege; Savi Appana; Liang Li; Jose Serrano; Jo Ann S Rinaudo; Mark Topazian; Darwin L Conwell Journal: Pancreatology Date: 2021-01-22 Impact factor: 3.996