Literature DB >> 23276723

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Jennifer C Naylor1, Trygve R Dolber, Jennifer L Strauss, Jason D Kilts, Timothy J Strauman, Daniel W Bradford, Steven T Szabo, Nagy A Youssef, Kathryn M Connor, Jonathan R T Davidson, Christine E Marx.   

Abstract

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD. Published by Elsevier Ireland Ltd.

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Year:  2012        PMID: 23276723      PMCID: PMC3788578          DOI: 10.1016/j.psychres.2012.11.008

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  11 in total

1.  Fluvoxamine reduces physiologic reactivity to trauma scripts in posttraumatic stress disorder.

Authors:  P Tucker; K L Smith; B Marx; D Jones; R Miranda; J Lensgraf
Journal:  J Clin Psychopharmacol       Date:  2000-06       Impact factor: 3.153

2.  The nature and course of subthreshold PTSD.

Authors:  Judith Cukor; Katarzyna Wyka; Nimali Jayasinghe; Joann Difede
Journal:  J Anxiety Disord       Date:  2010-06-25

3.  Delayed-onset PTSD: a prospective study of injury survivors.

Authors:  Jessica Carty; Meaghan L O'Donnell; Mark Creamer
Journal:  J Affect Disord       Date:  2005-12-27       Impact factor: 4.839

4.  Anger, hostility, and aggression among Iraq and Afghanistan War veterans reporting PTSD and subthreshold PTSD.

Authors:  Matthew Jakupcak; Daniel Conybeare; Lori Phelps; Stephen Hunt; Hollie A Holmes; Bradford Felker; Michele Klevens; Miles E McFall
Journal:  J Trauma Stress       Date:  2007-12

5.  Hopelessness and suicidal ideation in Iraq and Afghanistan War Veterans reporting subthreshold and threshold posttraumatic stress disorder.

Authors:  Matthew Jakupcak; Katherine D Hoerster; Alethea Varra; Steven Vannoy; Bradford Felker; Stephen Hunt
Journal:  J Nerv Ment Dis       Date:  2011-04       Impact factor: 2.254

6.  Full and partial posttraumatic stress disorder: findings from a community survey.

Authors:  M B Stein; J R Walker; A L Hazen; D R Forde
Journal:  Am J Psychiatry       Date:  1997-08       Impact factor: 18.112

7.  Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study.

Authors:  R D Marshall; K L Beebe; M Oldham; R Zaninelli
Journal:  Am J Psychiatry       Date:  2001-12       Impact factor: 18.112

8.  Partial posttraumatic stress disorder (PTSD): the issue of psychological scars and the occurrence of PTSD symptoms.

Authors:  I V Carlier; B P Gersons
Journal:  J Nerv Ment Dis       Date:  1995-02       Impact factor: 2.254

9.  Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study.

Authors:  Arieh Y Shalev; Yael Ankri; Yossi Israeli-Shalev; Tamar Peleg; Rhonda Adessky; Sara Freedman
Journal:  Arch Gen Psychiatry       Date:  2011-10-03

10.  Comorbidity, impairment, and suicidality in subthreshold PTSD.

Authors:  R D Marshall; M Olfson; F Hellman; C Blanco; M Guardino; E L Struening
Journal:  Am J Psychiatry       Date:  2001-09       Impact factor: 18.112

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  14 in total

1.  Rates of Subthreshold PTSD Among U.S. Military Veterans and Service Members: A Literature Review.

Authors:  Hannah E Bergman; Amy Przeworski; Norah C Feeny
Journal:  Mil Psychol       Date:  2016-12-19

Review 2.  Psychopharmacological strategies in the management of posttraumatic stress disorder (PTSD): what have we learned?

Authors:  Nancy C Bernardy; Matthew J Friedman
Journal:  Curr Psychiatry Rep       Date:  2015-04       Impact factor: 5.285

3.  Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys.

Authors:  Katie A McLaughlin; Karestan C Koenen; Matthew J Friedman; Ayelet Meron Ruscio; Elie G Karam; Victoria Shahly; Dan J Stein; Eric D Hill; Maria Petukhova; Jordi Alonso; Laura Helena Andrade; Matthias C Angermeyer; Guilherme Borges; Giovanni de Girolamo; Ron de Graaf; Koen Demyttenaere; Silvia E Florescu; Maya Mladenova; Jose Posada-Villa; Kate M Scott; Tadashi Takeshima; Ronald C Kessler
Journal:  Biol Psychiatry       Date:  2014-04-12       Impact factor: 13.382

4.  Effects of paroxetine on PTSD-like symptoms in mice.

Authors:  Yassine Bentefour; Mohamed Bennis; René Garcia; Saadia Ba M'hamed
Journal:  Psychopharmacology (Berl)       Date:  2015-01-15       Impact factor: 4.530

5.  Differential treatment response trajectories in individuals with subclinical and clinical PTSD.

Authors:  Kristina J Korte; Nicholas P Allan; Daniel F Gros; Ron Acierno
Journal:  J Anxiety Disord       Date:  2016-01-21

6.  The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.

Authors:  Mira Brancu; H Ryan Wagner; Rajendra A Morey; Jean C Beckham; Patrick S Calhoun; Larry A Tupler; Christine E Marx; Katherine H Taber; Robin A Hurley; Jared Rowland; Scott D McDonald; Jeffrey M Hoerle; Scott D Moore; Harold S Kudler; Richard D Weiner; John A Fairbank
Journal:  Int J Methods Psychiatr Res       Date:  2017-06-27       Impact factor: 4.035

Review 7.  Pharmacotherapy for post traumatic stress disorder (PTSD).

Authors:  Taryn Williams; Nicole J Phillips; Dan J Stein; Jonathan C Ipser
Journal:  Cochrane Database Syst Rev       Date:  2022-03-02

Review 8.  Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).

Authors:  Federico Bertolini; Lindsay Robertson; Jonathan I Bisson; Nicholas Meader; Rachel Churchill; Giovanni Ostuzzi; Dan J Stein; Taryn Williams; Corrado Barbui
Journal:  Cochrane Database Syst Rev       Date:  2022-02-10

9.  Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review.

Authors:  Hollie Melton; Nick Meader; Holly Dale; Kath Wright; Julie Jones-Diette; Melanie Temple; Iram Shah; Karina Lovell; Dean McMillan; Rachel Churchill; Corrado Barbui; Simon Gilbody; Peter Coventry
Journal:  Health Technol Assess       Date:  2020-09       Impact factor: 4.014

10.  Examining PTSD treatment choice among individuals with subthreshold PTSD.

Authors:  Hannah E Bergman; Alexander C Kline; Norah C Feeny; Lori A Zoellner
Journal:  Behav Res Ther       Date:  2015-07-22
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