Literature DB >> 23275850

Round Cell Vaginal Malignant Melanoma: A rare entity.

Neena Chauhan1, Dushyant S Gaur, Ved P Pathak.   

Abstract

Malignant melanoma is predominantly a skin disease but in rare instances it may occur at other sites. A vaginal melanoma is a rare clinical entity and the round cell type is an uncommon variant. Although the present case was clinically diagnosed as a urethral caruncle, on histopathological examination and immunostaining it was diagnosed as a round cell pigmented malignant melanoma. The patient refused radical surgery and was given a full course radiotherapy treatment but died a year later. Malignant vaginal melanoma carries a very poor prognosis even when lesion is localised at the time of presentation. The five-year survival rate ranges from 10-20% with the prognosis being influenced by tumour size. A tumour size ≥3cm has a poor prognosis. Age, mitotic count, stage, and location of the lesion do not influence survival rates.

Entities:  

Keywords:  Case report; Fontana-Masson stain; Immunohistochemical staining; India; Malignancy; Melanoma; Round cell tumors; Vagina

Year:  2012        PMID: 23275850      PMCID: PMC3524003          DOI: 10.12816/0003179

Source DB:  PubMed          Journal:  Sultan Qaboos Univ Med J        ISSN: 2075-051X


  6 in total

1.  Primary malignant melanoma of the vagina with repeated local recurrences and brain metastasis.

Authors:  Li-Te Lin; Chung-Bin Liu; San-Nung Chen; An-Jen Chiang; Wen-Shiung Liou; Ken-Jen Yu
Journal:  J Chin Med Assoc       Date:  2011-08-06       Impact factor: 2.743

Review 2.  A primary amelanotic melanoma of the vagina diagnosed by immunocytochemistry.

Authors:  G Scambia; P Benedetti Panici; G Baiocchi; A Coli; S Ferrone; P G Natali; S Mancuso
Journal:  Int J Gynaecol Obstet       Date:  1989-06       Impact factor: 3.561

3.  Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960-1984.

Authors:  B Ragnarsson-Olding; H Johansson; L E Rutqvist; U Ringborg
Journal:  Cancer       Date:  1993-03-01       Impact factor: 6.860

4.  Malignant melanoma of the vulva and vagina in the United States: patterns of incidence and population-based estimates of survival.

Authors:  M A Weinstock
Journal:  Am J Obstet Gynecol       Date:  1994-11       Impact factor: 8.661

5.  Malignant melanoma of the vagina--report of 19 cases.

Authors:  A F Chung; M J Casey; J T Flannery; J M Woodruff; J L Lewis
Journal:  Obstet Gynecol       Date:  1980-06       Impact factor: 7.661

6.  Primary vaginal melanoma: a critical analysis of therapy.

Authors:  Thomas J Miner; Ruby Delgado; Jonathan Zeisler; Klaus Busam; Kaled Alektiar; Richard Barakat; Elizabeth Poynor
Journal:  Ann Surg Oncol       Date:  2004-01       Impact factor: 5.344

  6 in total

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