Literature DB >> 23275848

Transient Myeloproliferative Disorder and Down Syndrome: Is there a link?

Zenaida S Reyes1, Wafa Bashir, Anil Pathare.   

Abstract

An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.

Entities:  

Keywords:  Acute myelogenous leukemia (AML); Case report; Down syndrome; Extreme premature; GATA1; Oman; Transient myeloproliferative disorder

Year:  2012        PMID： 23275848      PMCID： PMC3524001          DOI： 10.12816/0003177

Source DB:  PubMed          Journal:  Sultan Qaboos Univ Med J        ISSN： 2075-051X


  9 in total

Review 1.  Acute leukemia in children with Down syndrome.

Authors:  Ana C Xavier; Jeffrey W Taub
Journal:  Haematologica       Date:  2010-07       Impact factor: 9.941

Review 2.  Vascular compromise in newborn infants.

Authors:  D T Gault
Journal:  Arch Dis Child       Date:  1992-04       Impact factor: 3.791

Review 3.  Transient leukaemia--a benign form of leukaemia in newborn infants with trisomy 21.

Authors:  Alvin Zipursky
Journal:  Br J Haematol       Date:  2003-03       Impact factor: 6.998

4.  Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders.

Authors:  A Nijhawan; E Baselga; M A Gonzalez-Ensenat; A Vicente; J F Southern; B M Camitta; N B Esterly; B A Drolet
Journal:  Arch Dermatol       Date:  2001-06

Review 5.  Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.

Authors:  Anindita Roy; Irene Roberts; Alice Norton; Paresh Vyas
Journal:  Br J Haematol       Date:  2009-07-06       Impact factor: 6.998

6.  The phenotype of persons having mosaicism for trisomy 21/Down syndrome reflects the percentage of trisomic cells present in different tissues.

Authors:  Paulie Papavassiliou; Timothy P York; Nurcan Gursoy; Gloria Hill; Lauren Vanner Nicely; Usha Sundaram; Allison McClain; Steven H Aggen; Lindon Eaves; Brien Riley; Colleen Jackson-Cook
Journal:  Am J Med Genet A       Date:  2009-02-15       Impact factor: 2.802

7.  Transient myeloproliferative disorder associated with trisomy 21, a wide range syndrome: report of two cases with trisomy 21 mosaicism.

Authors:  P Zubizarreta; F S Muriel; M A Fernández Barbieri
Journal:  Med Pediatr Oncol       Date:  1995-07

8.  Vesiculopustular eruption associated with transient myeloproliferative disorder.

Authors:  Erika Nornhold; Anna Li; Ilene L Rothman; Satyan Lakshminrusimha; Thomas N Helm
Journal:  Cutis       Date:  2009-05

9.  A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481.

Authors:  Gita V Massey; Alvin Zipursky; Myron N Chang; John J Doyle; Suhail Nasim; Jeffrey W Taub; Yaddanapudi Ravindranath; Gary Dahl; Howard J Weinstein
Journal:  Blood       Date:  2006-02-09       Impact factor: 22.113
  9 in total
  1 in total

1.  Extreme hyperleucocytosis of the premature.

Authors:  Esther Jansen; Judith Emmen; Thilo Mohns; Albertine Donker
Journal:  BMJ Case Rep       Date:  2013-04-19
  1 in total

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