Literature DB >> 23275608

Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.

Sara Gianella1, Christy M Anderson, Milenka V Vargas, Douglas D Richman, Susan J Little, Sheldon R Morris, Davey M Smith.   

Abstract

Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.

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Year:  2012        PMID： 23275608      PMCID： PMC3571441          DOI： 10.1093/infdis/jis777

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Predictive value of provirus load and DNA human immunodeficiency virus genotype for successful abacavir-based simplified therapy.

Authors:  Isabelle Pellegrin; Anne Caumont; Isabelle Garrigue; Patrick Merel; Marie-Hélène Schrive; Hervé Fleury; Michel Dupon; Jean-Luc Pellegrin; Jean-Marie Ragnaud
Journal:  J Infect Dis       Date:  2002-12-13       Impact factor: 5.226

Review 2.  HIV and inflammation: mechanisms and consequences.

Authors:  Peter W Hunt
Journal:  Curr HIV/AIDS Rep       Date:  2012-06       Impact factor: 5.071

3.  HIV rebounds from latently infected cells, rather than from continuing low-level replication.

Authors:  Beda Joos; Marek Fischer; Herbert Kuster; Satish K Pillai; Joseph K Wong; Jürg Böni; Bernard Hirschel; Rainer Weber; Alexandra Trkola; Huldrych F Günthard
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-20       Impact factor: 11.205

4.  Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.

Authors:  Nicole H Tobin; Gerald H Learn; Sarah E Holte; Yang Wang; Ann J Melvin; Jennifer L McKernan; Diane M Pawluk; Kathleen M Mohan; Paul F Lewis; James I Mullins; Lisa M Frenkel
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

5.  Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.

Authors:  Matthew C Strain; Susan J Little; Eric S Daar; Diane V Havlir; Huldrych F Gunthard; Ruby Y Lam; Otto A Daly; Juin Nguyen; Caroline C Ignacio; Celsa A Spina; Douglas D Richman; Joseph K Wong
Journal:  J Infect Dis       Date:  2005-03-29       Impact factor: 5.226

6.  Early levels of HIV-1 DNA in peripheral blood mononuclear cells are predictive of disease progression independently of HIV-1 RNA levels and CD4+ T cell counts.

Authors:  Christine Rouzioux; Jean-Baptiste Hubert; Marianne Burgard; Christiane Deveau; Cécile Goujard; Marc Bary; Daniel Séréni; Jean-Paul Viard; Jean-François Delfraissy; Laurence Meyer
Journal:  J Infect Dis       Date:  2005-05-31       Impact factor: 5.226

7.  HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study.

Authors:  V G Valcour; B T Shiramizu; P Sithinamsuwan; S Nidhinandana; S Ratto-Kim; J Ananworanich; U Siangphoe; J H Kim; M de Souza; V Degruttola; R H Paul; C M Shikuma
Journal:  Neurology       Date:  2009-03-17       Impact factor: 9.910

8.  Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

Authors:  Susan J Little; Simon D W Frost; Joseph K Wong; Davey M Smith; Sergei L Kosakovsky Pond; Caroline C Ignacio; Neil T Parkin; Christos J Petropoulos; Douglas D Richman
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

9.  Biphasic decay kinetics suggest progressive slowing in turnover of latently HIV-1 infected cells during antiretroviral therapy.

Authors:  Marek Fischer; Beda Joos; Barbara Niederöst; Philipp Kaiser; Roland Hafner; Viktor von Wyl; Martina Ackermann; Rainer Weber; Huldrych F Günthard
Journal:  Retrovirology       Date:  2008-11-26       Impact factor: 4.602

10.  Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.

Authors:  Afam Okoye; Martin Meier-Schellersheim; Jason M Brenchley; Shoko I Hagen; Joshua M Walker; Mukta Rohankhedkar; Richard Lum; John B Edgar; Shannon L Planer; Alfred Legasse; Andrew W Sylwester; Michael Piatak; Jeffrey D Lifson; Vernon C Maino; Donald L Sodora; Daniel C Douek; Michael K Axthelm; Zvi Grossman; Louis J Picker
Journal:  J Exp Med       Date:  2007-08-27       Impact factor: 14.307
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  39 in total

Review 1.  Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection.

Authors:  Michael L Freeman; Michael M Lederman; Sara Gianella
Journal:  Curr HIV/AIDS Rep       Date:  2016-02       Impact factor: 5.071

Review 2.  Measuring the latent reservoir in vivo.

Authors:  Marta Massanella; Douglas D Richman
Journal:  J Clin Invest       Date:  2016-02-01       Impact factor: 14.808

3.  Seminal plasma and semen amyloids enhance cytomegalovirus infection in cell culture.

Authors:  Qiyi Tang; Nadia R Roan; Yasuhiro Yamamura
Journal:  J Virol       Date:  2013-09-11       Impact factor: 5.103

4.  Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy.

Authors:  G Matusali; N Dereuddre-Bosquet; A Le Tortorec; M Moreau; A-P Satie; D Mahé; P Roumaud; O Bourry; N Sylla; S Bernard-Stoecklin; A Pruvost; R Le Grand; N Dejucq-Rainsford
Journal:  J Virol       Date:  2015-04-01       Impact factor: 5.103

Review 5.  Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications.

Authors:  Véronique Avettand-Fènoël; Laurent Hocqueloux; Jade Ghosn; Antoine Cheret; Pierre Frange; Adeline Melard; Jean-Paul Viard; Christine Rouzioux
Journal:  Clin Microbiol Rev       Date:  2016-10       Impact factor: 26.132

Review 6.  The Sordid Affair Between Human Herpesvirus and HIV.

Authors:  Sara Gianella; Marta Massanella; Joel O Wertheim; Davey M Smith
Journal:  J Infect Dis       Date:  2015-03-06       Impact factor: 5.226

Review 7.  Cytomegalovirus and HIV Persistence: Pouring Gas on the Fire.

Authors:  Aaron Christensen-Quick; Christophe Vanpouille; Andrea Lisco; Sara Gianella
Journal:  AIDS Res Hum Retroviruses       Date:  2017-11       Impact factor: 2.205

8.  Time course of cellular HIV-DNA and low-level HIV viremia in HIV-HCV co-infected patients whose HCV infection had been successfully treated with directly acting antivirals.

Authors:  Saverio G Parisi; Samantha Andreis; Monica Basso; Silvia Cavinato; Renzo Scaggiante; Marzia Franzetti; Massimo Andreoni; Giorgio Palù; Anna Maria Cattelan
Journal:  Med Microbiol Immunol       Date:  2017-09-01       Impact factor: 3.402

Review 9.  Cytomegalovirus and HIV: A Dangerous Pas de Deux.

Authors:  Sara Gianella; Scott Letendre
Journal:  J Infect Dis       Date:  2016-10-01       Impact factor: 5.226

Review 10.  Residual inflammation and viral reservoirs: alliance against an HIV cure.

Authors:  Marta Massanella; Rémi Fromentin; Nicolas Chomont
Journal:  Curr Opin HIV AIDS       Date:  2016-03       Impact factor: 4.283
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