CONTEXT: Schistosome antigens modulate host metabolic profiles and reduce the risk of diabetes in experimental animals. This association has not previously been examined in humans. OBJECTIVE: The objective of the study was to evaluate whether previous schistosome infection (PSI) is related to the development of diabetes and metabolic syndrome. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study was conducted in 9539 participants aged 40 years and older in a rural community in China. MAIN OUTCOME MEASURES: Information on a history of schistosome infection was collected by personal interview and cross-referenced with local infectious disease registry. The associations between PSI and diabetes or metabolic profiles were evaluated using logistic regression models in participants aged 60 years and older (n = 3913). RESULTS: Participants with PSI (n = 463) had significantly lower levels of adjusted fasting blood glucose, postprandial blood glucose, glycated hemoglobin A1c, and homeostasis model assessment of insulin resistance as well as a lower prevalence of diabetes (14.9% vs 25.4%, P < .0001) and metabolic syndrome (14.0% vs. 35.0%, P < .0001) compared with the uninfected, contemporaneous controls (n = 3450). Logistic regression analysis revealed that the adjusted odds ratios and 95% confidence interval of prevalent diabetes and metabolic syndrome associated with PSI were 0.51 (0.34-0.77) and 0.40 (0.27-0.58), respectively. CONCLUSIONS: The associations between PSI and the lower prevalence of diabetes and a better metabolic profile in rural Chinese need to be confirmed in other populations. If confirmed, the protecting effect of helminth infection could be reconsidered in terms of therapeutic strategies for the treatment of diabetes and metabolic diseases.
CONTEXT: Schistosome antigens modulate host metabolic profiles and reduce the risk of diabetes in experimental animals. This association has not previously been examined in humans. OBJECTIVE: The objective of the study was to evaluate whether previous schistosome infection (PSI) is related to the development of diabetes and metabolic syndrome. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study was conducted in 9539 participants aged 40 years and older in a rural community in China. MAIN OUTCOME MEASURES: Information on a history of schistosome infection was collected by personal interview and cross-referenced with local infectious disease registry. The associations between PSI and diabetes or metabolic profiles were evaluated using logistic regression models in participants aged 60 years and older (n = 3913). RESULTS:Participants with PSI (n = 463) had significantly lower levels of adjusted fasting blood glucose, postprandial blood glucose, glycated hemoglobin A1c, and homeostasis model assessment of insulin resistance as well as a lower prevalence of diabetes (14.9% vs 25.4%, P < .0001) and metabolic syndrome (14.0% vs. 35.0%, P < .0001) compared with the uninfected, contemporaneous controls (n = 3450). Logistic regression analysis revealed that the adjusted odds ratios and 95% confidence interval of prevalent diabetes and metabolic syndrome associated with PSI were 0.51 (0.34-0.77) and 0.40 (0.27-0.58), respectively. CONCLUSIONS: The associations between PSI and the lower prevalence of diabetes and a better metabolic profile in rural Chinese need to be confirmed in other populations. If confirmed, the protecting effect of helminth infection could be reconsidered in terms of therapeutic strategies for the treatment of diabetes and metabolic diseases.
Authors: Di Cheng; Chunyan Hu; Rui Du; Hongyan Qi; Lin Lin; Xueyan Wu; Lina Ma; Kui Peng; Mian Li; Min Xu; Yu Xu; Yufang Bi; Weiqing Wang; Yuhong Chen; Jieli Lu Journal: Front Med Date: 2020-04-29 Impact factor: 4.592
Authors: Diana Cortes-Selva; Andrew F Elvington; Andrew Ready; Bartek Rajwa; Edward J Pearce; Gwendalyn J Randolph; Keke C Fairfax Journal: Front Immunol Date: 2018-11-12 Impact factor: 7.561
Authors: Aprilianto E Wiria; Firdaus Hamid; Linda J Wammes; Margaretta A Prasetyani; Olaf M Dekkers; Linda May; Maria M M Kaisar; Jaco J Verweij; Bruno Guigas; Felix Partono; Erliyani Sartono; Taniawati Supali; Maria Yazdanbakhsh; Johannes W A Smit Journal: PLoS One Date: 2015-06-10 Impact factor: 3.240