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Literature DB >> 23274670

Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.

Yohei Iizaka¹, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, Moeka Takeda, Yojiro Anzai, Fumio Kato.

Abstract

The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Escherichia coli expressing RosC and RosD. It is proposed that M. rosaria IFO13697 has two pathway branches that lead from the first desosaminyl rosamicin intermediate, 20-deoxo-20-dihydro-12,13-deepoxyrosamicin, to rosamicin.

Entities: Chemical Species

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Year: 2012 PMID： 23274670 PMCID： PMC3591866 DOI： 10.1128/AAC.02092-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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8 in total

1. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.

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Review 2. An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.

Authors: Yohei Iizaka; David H Sherman; Yojiro Anzai
Journal: Appl Microbiol Biotechnol Date: 2021-03-12 Impact factor: 4.813

3. Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins.

Authors: Tucker Maxson; Jonathan I Tietz; Graham A Hudson; Xiao Rui Guo; Hua-Chia Tai; Douglas A Mitchell
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4. A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the D-mycinose biosynthetic gene.

Authors: Yohei Iizaka; Noriko Higashi; Wei Li; Atsushi Fukumoto; Yojiro Anzai; Fumio Kato
Journal: J Ind Microbiol Biotechnol Date: 2014-07-22 Impact factor: 3.346

5. Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Authors: Andrew N Lowell; Matthew D DeMars; Samuel T Slocum; Fengan Yu; Krithika Anand; Joseph A Chemler; Nisha Korakavi; Jennifer K Priessnitz; Sung Ryeol Park; Aaron A Koch; Pamela J Schultz; David H Sherman
Journal: J Am Chem Soc Date: 2017-06-05 Impact factor: 15.419