| Literature DB >> 23274150 |
Melissa Swiecki1, Natalie S Omattage, Tom J Brett.
Abstract
BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.Entities:
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Year: 2012 PMID： 23274150 DOI： 10.1016/j.molimm.2012.11.008
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407