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Literature DB >> 23273742

A dancer caught midstep: the structure of ATP-bound Hsp70.

Abstract

Hsp70 ATP binding induces substrate release, but the transiency of this state has inhibited its characterization. In this issue, Kityk et al. determine the Hsp70(∗)ATP structure utilizing engineered disulfide bonds, providing insights into the workings of this essential molecular machine.

Entities: Chemical Disease Gene Mutation Species

Year: 2012 PMID： 23273742 PMCID： PMC3746503 DOI： 10.1016/j.molcel.2012.12.008

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

8 in total

1. Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.

Authors: Moritz Marcinowski; Matthias Höller; Matthias J Feige; Danae Baerend; Don C Lamb; Johannes Buchner
Journal: Nat Struct Mol Biol Date: 2011-01-09 Impact factor: 15.369

2. Structural basis of J cochaperone binding and regulation of Hsp70.

Authors: Jianwen Jiang; E Guy Maes; Alexander B Taylor; Liping Wang; Andrew P Hinck; Eileen M Lafer; Rui Sousa
Journal: Mol Cell Date: 2007-11-09 Impact factor: 17.970

3. Mechanics of Hsp70 chaperones enables differential interaction with client proteins.

Authors: Rainer Schlecht; Annette H Erbse; Bernd Bukau; Matthias P Mayer
Journal: Nat Struct Mol Biol Date: 2011-01-30 Impact factor: 15.369

4. Structural analysis of substrate binding by the molecular chaperone DnaK.

Authors: X Zhu; X Zhao; W F Burkholder; A Gragerov; C M Ogata; M E Gottesman; W A Hendrickson
Journal: Science Date: 1996-06-14 Impact factor: 47.728

5. Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.

Authors: Roman Kityk; Jürgen Kopp; Irmgard Sinning; Matthias P Mayer
Journal: Mol Cell Date: 2012-11-01 Impact factor: 17.970

6. Direct comparison of a stable isolated Hsp70 substrate-binding domain in the empty and substrate-bound states.

Authors: Joanna F Swain; Edda G Schulz; Lila M Gierasch
Journal: J Biol Chem Date: 2005-11-06 Impact factor: 5.157

7. Kinetics of molecular chaperone action.

Authors: D Schmid; A Baici; H Gehring; P Christen
Journal: Science Date: 1994-02-18 Impact factor: 47.728

8. Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.

Authors: Eric B Bertelsen; Lyra Chang; Jason E Gestwicki; Erik R P Zuiderweg
Journal: Proc Natl Acad Sci U S A Date: 2009-05-13 Impact factor: 11.205

8 in total

4 in total

Review 1. The chaperone toolbox at the single-molecule level: From clamping to confining.

Authors: Mario J Avellaneda; Eline J Koers; Mohsin M Naqvi; Sander J Tans
Journal: Protein Sci Date: 2017-04-20 Impact factor: 6.725

2. Putative model for heat shock protein 70 complexation with receptor of advanced glycation end products through fluorescence proximity assays and normal mode analyses.

Authors: Marcelo Sartori Grunwald; Rodrigo Ligabue-Braun; Cristiane Santos Souza; Luana Heimfarth; Hugo Verli; Daniel Pens Gelain; José Cláudio Fonseca Moreira
Journal: Cell Stress Chaperones Date: 2016-11-17 Impact factor: 3.667

3. Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove.

Authors: Karin M Rohrer; Markus Haug; Daniela Schwörer; Hubert Kalbacher; Ursula Holzer
Journal: Immunology Date: 2014-06 Impact factor: 7.397

Review 4. Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones.

Authors: Andrija Finka; Sandeep K Sharma; Pierre Goloubinoff
Journal: Front Mol Biosci Date: 2015-06-05

4 in total