Literature DB >> 23272941

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8.

David E Williams1, Doralyn S Dalisay, Fengling Li, James Amphlett, Wisanu Maneerat, Miguel Angel Garcia Chavez, Yan Alexander Wang, Teatulohi Matainaho, Wenyu Yu, Peter J Brown, Cheryl H Arrowsmith, Masoud Vedadi, Raymond J Andersen.   

Abstract

The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data.

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Year:  2012        PMID： 23272941     DOI： 10.1021/ol303416k

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  29 in total

Review 1.  Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.

Authors:  Zhanxin Wang; Dinshaw J Patel
Journal:  Q Rev Biophys       Date:  2013-09-02       Impact factor: 5.318

Review 2.  Inhibitors of Protein Methyltransferases and Demethylases.

Authors:  H Ümit Kaniskan; Michael L Martini; Jian Jin
Journal:  Chem Rev       Date:  2017-03-24       Impact factor: 60.622

Review 3.  Recent progress in developing selective inhibitors of protein methyltransferases.

Authors:  H Ümit Kaniskan; Jian Jin
Journal:  Curr Opin Chem Biol       Date:  2017-06-26       Impact factor: 8.822

4.  Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.

Authors:  Russell A Judge; Haizhong Zhu; Anup K Upadhyay; Pierre M Bodelle; Charles W Hutchins; Maricel Torrent; Violeta L Marin; Wenyu Yu; Masoud Vedadi; Fengling Li; Peter J Brown; William N Pappano; Chaohong Sun; Andrew M Petros
Journal:  ACS Med Chem Lett       Date:  2016-10-11       Impact factor: 4.345

Review 5.  Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.

Authors:  David F Tough; Huw D Lewis; Inmaculada Rioja; Matthew J Lindon; Rab K Prinjha
Journal:  Br J Pharmacol       Date:  2014-11       Impact factor: 8.739

Review 6.  Epigenetic drug discovery: a success story for cofactor interference.

Authors:  A Ganesan
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-05       Impact factor: 6.237

Review 7.  Clinically Applicable Inhibitors Impacting Genome Stability.

Authors:  Anu Prakash; Juan F Garcia-Moreno; James A L Brown; Emer Bourke
Journal:  Molecules       Date:  2018-05-13       Impact factor: 4.411

8.  Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.

Authors:  Hao Zhou; Xin Che; Guochen Bao; Na Wang; Li Peng; Kimberly D Barnash; Stephen V Frye; Lindsey I James; Xu Bai
Journal:  Bioorg Med Chem Lett       Date:  2016-08-03       Impact factor: 2.823

9.  An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

Authors:  Kyle D Konze; Anqi Ma; Fengling Li; Dalia Barsyte-Lovejoy; Trevor Parton; Christopher J Macnevin; Feng Liu; Cen Gao; Xi-Ping Huang; Ekaterina Kuznetsova; Marie Rougie; Alice Jiang; Samantha G Pattenden; Jacqueline L Norris; Lindsey I James; Bryan L Roth; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Klaus M Hahn; Gang Greg Wang; Masoud Vedadi; Jian Jin
Journal:  ACS Chem Biol       Date:  2013-04-24       Impact factor: 5.100

10.  Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

Authors:  Feng Liu; Dalia Barsyte-Lovejoy; Fengling Li; Yan Xiong; Victoria Korboukh; Xi-Ping Huang; Abdellah Allali-Hassani; William P Janzen; Bryan L Roth; Stephen V Frye; Cheryl H Arrowsmith; Peter J Brown; Masoud Vedadi; Jian Jin
Journal:  J Med Chem       Date:  2013-10-31       Impact factor: 7.446
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