Literature DB >> 23272914

Inhibition of PI3K/Akt/mTOR signaling by natural products.

Shile Huang.   

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Year:  2013        PMID： 23272914      PMCID： PMC3775843          DOI： 10.2174/1871520611313070001

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


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2.  Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Authors:  D D Sarbassov; David A Guertin; Siraj M Ali; David M Sabatini
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3.  Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Authors:  Emilie Vander Haar; Seong-Il Lee; Sricharan Bandhakavi; Timothy J Griffin; Do-Hyung Kim
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4.  mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Authors:  Maria A Frias; Carson C Thoreen; Jacob D Jaffe; Wayne Schroder; Tom Sculley; Steven A Carr; David M Sabatini
Journal:  Curr Biol       Date:  2006-08-17       Impact factor: 10.834

5.  Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.

Authors:  Qian Yang; Ken Inoki; Tsuneo Ikenoue; Kun-Liang Guan
Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

6.  SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Authors:  Estela Jacinto; Valeria Facchinetti; Dou Liu; Nelyn Soto; Shiniu Wei; Sung Yun Jung; Qiaojia Huang; Jun Qin; Bing Su
Journal:  Cell       Date:  2006-09-07       Impact factor: 41.582

7.  Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Authors:  D D Sarbassov; Siraj M Ali; Do-Hyung Kim; David A Guertin; Robert R Latek; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
Journal:  Curr Biol       Date:  2004-07-27       Impact factor: 10.834

8.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Authors:  Estela Jacinto; Robbie Loewith; Anja Schmidt; Shuo Lin; Markus A Rüegg; Alan Hall; Michael N Hall
Journal:  Nat Cell Biol       Date:  2004-10-03       Impact factor: 28.824

Review 9.  Rheb fills a GAP between TSC and TOR.

Authors:  Brendan D Manning; Lewis C Cantley
Journal:  Trends Biochem Sci       Date:  2003-11       Impact factor: 13.807

10.  Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Authors:  Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
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2.  HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy.

Authors:  Ju-Hee Lee; Kyung Hee Jung; Hyunseung Lee; Mi Kwon Son; Sun-Mi Yun; Sung-Hoon Ahn; Kyeong-Ryoon Lee; Soyoung Lee; Donghee Kim; Sungwoo Hong; Soon-Sun Hong
Journal:  Oncotarget       Date:  2014-10-30

3.  Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

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Journal:  J Transl Med       Date:  2014-07-21       Impact factor: 5.531

Review 4.  PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis.

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5.  Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin.

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Review 6.  Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents.

Authors:  Yu Liu; Wen-Zhu Wan; Yan Li; Guan-Lian Zhou; Xin-Guang Liu
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7.  Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition.

Authors:  Farid Ahmad Siddiqui; Gopinath Prakasam; Shilpi Chattopadhyay; Asad Ur Rehman; Rayees Ahmad Padder; Mohammad Afaque Ansari; Rasha Irshad; Kailash Mangalhara; Rameshwar N K Bamezai; Mohammad Husain; Syed Mansoor Ali; Mohammad Askandar Iqbal
Journal:  Sci Rep       Date:  2018-05-29       Impact factor: 4.379

8.  mTOR: A possible therapeutic target against SARS-CoV-2 infection.

Authors:  Nabab Khan
Journal:  Arch Stem Cell Ther       Date:  2021

9.  Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway.

Authors:  Xiaojuan Li; Yunping Tang; Fangmiao Yu; Yu Sun; Fangfang Huang; Yan Chen; Zuisu Yang; Guofang Ding
Journal:  Mar Drugs       Date:  2018-09-11       Impact factor: 5.118

Review 10.  Natural products as home-based prophylactic and symptom management agents in the setting of COVID-19.

Authors:  Sai Manohar Thota; Venkatesh Balan; Venketesh Sivaramakrishnan
Journal:  Phytother Res       Date:  2020-08-17       Impact factor: 6.388
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