Literature DB >> 23272792

Polypharmacology: drug discovery for the future.

A Srinivas Reddy1, Shuxing Zhang.   

Abstract

In recent years, even with remarkable scientific advancements and a significant increase of global research and development spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets, coined as polypharmacology, and the unintended drug-target interactions could cause side effects. Polypharmacology remains one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective, but less toxic, therapeutic agents. This review outlines the latest progress and challenges in polypharmacology studies.

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Year:  2013        PMID： 23272792      PMCID： PMC3809828          DOI： 10.1586/ecp.12.74

Source DB:  PubMed          Journal:  Expert Rev Clin Pharmacol        ISSN： 1751-2433            Impact factor:   5.045


  83 in total

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Journal:  Nat Biotechnol       Date:  2006-07       Impact factor: 54.908

Review 3.  The model organism as a system: integrating 'omics' data sets.

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Journal:  Nat Rev Mol Cell Biol       Date:  2006-03       Impact factor: 94.444

4.  Network pharmacology.

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Journal:  Nat Biotechnol       Date:  2007-10       Impact factor: 54.908

Review 5.  Systems pharmacology: network analysis to identify multiscale mechanisms of drug action.

Authors:  Shan Zhao; Ravi Iyengar
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012       Impact factor: 13.820

6.  The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment.

Authors:  K Durongpisitkul; V J Gururaj; J M Park; C F Martin
Journal:  Pediatrics       Date:  1995-12       Impact factor: 7.124

Review 7.  Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer.

Authors:  Susanna V Ulahannan; Julie R Brahmer
Journal:  Cancer Invest       Date:  2011-05       Impact factor: 2.176

8.  PubChem's BioAssay Database.

Authors:  Yanli Wang; Jewen Xiao; Tugba O Suzek; Jian Zhang; Jiyao Wang; Zhigang Zhou; Lianyi Han; Karen Karapetyan; Svetlana Dracheva; Benjamin A Shoemaker; Evan Bolton; Asta Gindulyte; Stephen H Bryant
Journal:  Nucleic Acids Res       Date:  2011-12-02       Impact factor: 16.971

9.  The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study.

Authors:  Allan P Davis; Cynthia G Murphy; Michael C Rosenstein; Thomas C Wiegers; Carolyn J Mattingly
Journal:  BMC Med Genomics       Date:  2008-10-09       Impact factor: 3.063

10.  A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Authors:  Jacob D Durrant; Rommie E Amaro; Lei Xie; Michael D Urbaniak; Michael A J Ferguson; Antti Haapalainen; Zhijun Chen; Anne Marie Di Guilmi; Frank Wunder; Philip E Bourne; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2010-01-22       Impact factor: 4.475
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  105 in total

Review 1.  Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.

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Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-03-23       Impact factor: 13.820

2.  A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells.

Authors:  Syed Muhammad Usama; Bosheng Zhao; Kevin Burgess
Journal:  Bioconjug Chem       Date:  2019-04-01       Impact factor: 4.774

3.  Validation strategies for target prediction methods.

Authors:  Neann Mathai; Ya Chen; Johannes Kirchmair
Journal:  Brief Bioinform       Date:  2020-05-21       Impact factor: 11.622

4.  A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling.

Authors:  Hong-Yu Lin; Joseph A Haegele; Michael T Disare; Qishan Lin; Yimon Aye
Journal:  J Am Chem Soc       Date:  2015-05-05       Impact factor: 15.419

5.  A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Authors:  Mingzhao Zhu; Wayne D Harshbarger; Omar Robles; Joanna Krysiak; Kenneth G Hull; Sung Wook Cho; Robyn D Richardson; Yanyan Yang; Andres Garcia; Lindsey Spiegelman; Bianca Ramirez; Christopher T Wilson; Ju Anne Yau; James T Moore; Caitlen B Walker; James C Sacchettini; Wenshe R Liu; Stephan A Sieber; Jeffrey W Smith; Daniel Romo
Journal:  Bioorg Med Chem       Date:  2017-01-19       Impact factor: 3.641

6.  Binding site matching in rational drug design: algorithms and applications.

Authors:  Misagh Naderi; Jeffrey Mitchell Lemoine; Rajiv Gandhi Govindaraj; Omar Zade Kana; Wei Pan Feinstein; Michal Brylinski
Journal:  Brief Bioinform       Date:  2019-11-27       Impact factor: 11.622

7.  A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.

Authors:  Yuanyuan Chen; Hong Tang; William Seibel; Ruben Papoian; Xiaoyu Li; Nevin A Lambert; Krzysztof Palczewski
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-04       Impact factor: 4.799

8.  Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

Authors:  Sean D Kodani; Saavan Bhakta; Sung Hee Hwang; Svetlana Pakhomova; Marcia E Newcomer; Christophe Morisseau; Bruce D Hammock
Journal:  Bioorg Med Chem Lett       Date:  2018-01-04       Impact factor: 2.823

9.  Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data.

Authors:  David Xu; Donghui Zhou; Khuchtumur Bum-Erdene; Barbara J Bailey; Kamakshi Sishtla; Sheng Liu; Jun Wan; Uma K Aryal; Jonathan A Lee; Clark D Wells; Melissa L Fishel; Timothy W Corson; Karen E Pollok; Samy O Meroueh
Journal:  ACS Chem Biol       Date:  2020-05-21       Impact factor: 5.100

Review 10.  Discovery and development of natural product oridonin-inspired anticancer agents.

Authors:  Ye Ding; Chunyong Ding; Na Ye; Zhiqing Liu; Eric A Wold; Haiying Chen; Christopher Wild; Qiang Shen; Jia Zhou
Journal:  Eur J Med Chem       Date:  2016-06-13       Impact factor: 6.514
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