Literature DB >> 23272698

Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines.

Jinsong Peng1, Guoning Shang, Chunxia Chen, Zhongshuo Miao, Bin Li.   

Abstract

An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.

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Year:  2013        PMID： 23272698     DOI： 10.1021/jo302471z

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Palladium-catalyzed regioselective synthesis of 2(2'-biphenyl)benzimidazoles through C-H activation.

Authors:  Li-Hsun Chen; Tz-Yi Wu; Vijaykumar Paike; Chung-Ming Sun
Journal:  Mol Divers       Date:  2013-07-19       Impact factor: 2.943

Review 2.  Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles.

Authors:  Dylan J Twardy; Kraig A Wheeler; Béla Török; Roman Dembinski
Journal:  Molecules       Date:  2022-03-23       Impact factor: 4.411

3.  Cs2CO3-Promoted reaction of tertiary bromopropargylic alcohols and phenols in DMF: a novel approach to α-phenoxyketones.

Authors:  Ol'ga G Volostnykh; Olesya A Shemyakina; Anton V Stepanov; Igor' A Ushakov
Journal:  Beilstein J Org Chem       Date:  2022-04-12       Impact factor: 2.544
  3 in total

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