| Literature DB >> 23271482 |
Karl L Skorecki1, Walter G Wasser.
Abstract
Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.Entities:
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Year: 2013 PMID: 23271482 DOI: 10.1038/ki.2012.369
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612