Literature DB >> 23271120

Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle.

Dongyep Oh1, Boomi La, Yoonseok Lee, Younhwa Byun, Jeayoung Lee, Geunhye Yeo, Jungsou Yeo.   

Abstract

The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G>A, c.329A>T, c.527T>G, c.988C>T and c.1591G>A), and confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G>A, c.329A>T, and GA genotype of c.1591G>A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.

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Year:  2012        PMID： 23271120     DOI： 10.1007/s11033-012-2389-y

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  19 in total

1.  Effects of fatty acids on meat quality: a review.

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Journal:  Meat Sci       Date:  2004-01       Impact factor: 5.209

2.  A novel single nucleotide polymorphism in exon 7 of LPL gene and its association with carcass traits and visceral fat deposition in yak (Bos grunniens) steers.

Authors:  X Z Ding; C N Liang; X Guo; C F Xing; P J Bao; M Chu; J Pei; X S Zhu; P Yan
Journal:  Mol Biol Rep       Date:  2011-05-06       Impact factor: 2.316

3.  In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake.

Authors:  P J Voshol; M C Jong; V E Dahlmans; D Kratky; S Levak-Frank; R Zechner; J A Romijn; L M Havekes
Journal:  Diabetes       Date:  2001-11       Impact factor: 9.461

4.  Quantitative trait loci with additive effects on palatability and fatty acid composition of meat in a Wagyu-Limousin F2 population.

Authors:  L J Alexander; M D Macneil; T W Geary; W M Snelling; D C Rule; J A Scanga
Journal:  Anim Genet       Date:  2007-10       Impact factor: 3.169

Review 5.  The lipase gene family.

Authors:  Howard Wong; Michael C Schotz
Journal:  J Lipid Res       Date:  2002-07       Impact factor: 5.922

Review 6.  A systemic review of the roles of n-3 fatty acids in health and disease.

Authors:  Natalie D Riediger; Rgia A Othman; Miyoung Suh; Mohammed H Moghadasian
Journal:  J Am Diet Assoc       Date:  2009-04

7.  Lipoprotein lipase domain function.

Authors:  H Wong; R C Davis; T Thuren; J W Goers; J Nikazy; M Waite; M C Schotz
Journal:  J Biol Chem       Date:  1994-04-08       Impact factor: 5.157

8.  Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis.

Authors:  L L Rudel; J S Parks; J K Sawyer
Journal:  Arterioscler Thromb Vasc Biol       Date:  1995-12       Impact factor: 8.311

9.  Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome.

Authors:  Michael A Eberle; Mark J Rieder; Leonid Kruglyak; Deborah A Nickerson
Journal:  PLoS Genet       Date:  2006-07-25       Impact factor: 5.917

10.  Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle.

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Journal:  BMC Genet       Date:  2008-12-11       Impact factor: 2.797
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  5 in total

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Authors:  Mohamed E Abd El-Hack; Sameh A Abdelnour; Ayman A Swelum; Muhammad Arif
Journal:  Mol Biol Rep       Date:  2018-07-13       Impact factor: 2.316

Review 2.  Candidate Genes and Their Expressions Involved in the Regulation of Milk and Meat Production and Quality in Goats (Capra hircus).

Authors:  Jose Ignacio Salgado Pardo; Juan Vicente Delgado Bermejo; Antonio González Ariza; José Manuel León Jurado; Carmen Marín Navas; Carlos Iglesias Pastrana; María Del Amparo Martínez Martínez; Francisco Javier Navas González
Journal:  Animals (Basel)       Date:  2022-04-11       Impact factor: 3.231

3.  Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables.

Authors:  Laiza Helena de Souza Iung; Herman Arend Mulder; Haroldo Henrique de Rezende Neves; Roberto Carvalheiro
Journal:  BMC Genomics       Date:  2018-08-16       Impact factor: 3.969

4.  Transcriptome Analysis of the Liver and Muscle Tissues of Dorper and Small-Tailed Han Sheep.

Authors:  Hongyang Peng; Mingyue Hu; Zhengxi Liu; Weining Lai; Lulu Shi; Zhongli Zhao; Huihai Ma; Yumei Li; Shouqing Yan
Journal:  Front Genet       Date:  2022-04-11       Impact factor: 4.772

5.  Genome-wide association and genomic prediction of breeding values for fatty acid composition in subcutaneous adipose and longissimus lumborum muscle of beef cattle.

Authors:  Liuhong Chen; Chinyere Ekine-Dzivenu; Michael Vinsky; John Basarab; Jennifer Aalhus; Mike E R Dugan; Carolyn Fitzsimmons; Paul Stothard; Changxi Li
Journal:  BMC Genet       Date:  2015-11-21       Impact factor: 2.797
  5 in total

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