| Literature DB >> 23270309 |
Brian A Sparling1, David C Moebius, Matthew D Shair.
Abstract
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.Entities:
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Year: 2012 PMID： 23270309 DOI： 10.1021/ja312150d
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419