Literature DB >> 23269790

T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus.

Werner J D Ouwendijk1, Allison Abendroth, Vicki Traina-Dorge, Sarah Getu, Megan Steain, Mary Wellish, Arno C Andeweg, Albert D M E Osterhaus, Don Gilden, Georges M G M Verjans, Ravi Mahalingam.   

Abstract

Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

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Year:  2012        PMID: 23269790      PMCID: PMC3571377          DOI: 10.1128/JVI.03181-12

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


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