Literature DB >> 2326762

Levels of multiallelic overdominance fitness, heterozygote excess and heterozygote deficiency.

S Karlin1.   

Abstract

Concepts and results on selection balance in multiallelic systems are described. These include a multidimensional concept of heterozygote excess and heterozygote deficiency, a hierarchy of means of assessment of heterozygote advantage, comparisons and contrasts of allelic versus gametic polymorphic states, and conditions defining stable equilibria of complementary gametic sets. The concepts are illustrated in the context of viability selection and behavioral models of kin selection and for two major categories of multilocus selection regimes.

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Year:  1990        PMID: 2326762     DOI: 10.1016/0040-5809(90)90031-p

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  1 in total

1.  CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess.

Authors:  Nicolas von Ahsen; Mladen Tzvetkov; Harin A Karunajeewa; Servina Gomorrai; Alice Ura; Jürgen Brockmöller; Timothy M E Davis; Ivo Mueller; Kenneth F Ilett; Michael Oellerich
Journal:  Int J Mol Epidemiol Genet       Date:  2010-08-18
  1 in total

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