Literature DB >> 23267157

Prognostic impact of prophylactic splenectomy for upper-third gastric cancer: a cohort study.

Hiroaki Ito1, Haruhiro Inoue, Noriko Odaka, Hitoshi Satodate, Shumpei Mukai, Tomokatsu Omoto, Yusuke Takehara, Shin-Ei Kudo.   

Abstract

AIM: The aim of this study was to investigate the effect of splenectomy on survival outcomes and recurrence in patients who underwent curative surgery for gastric cancer. PATIENTS AND METHODS: This is a retrospective study of 129 patients who underwent upper-third gastric cancer curative resection with lymphadenectomy. Forty-two patients (32%) also underwent splenectomy.
RESULTS: The median follow-up period was 33 months. Approximately 40% of the patients had lymph node metastases; four of them had nodal involvement along the splenic artery and 5 had nodal involvement at the splenic hilum. No patients in the pT1-2 group with nodal metastases had involvement of the splenic hilar lymph nodes. There was no significant association between splenectomy and either overall or disease-free survival in the patients.
CONCLUSION: Splenectomy should not be performed in patients with pT1-2 tumors for prophylactic lymphadenectomy.

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Year:  2013        PMID: 23267157

Source DB:  PubMed          Journal:  Anticancer Res        ISSN: 0250-7005            Impact factor:   2.480


  4 in total

Review 1.  Gastric cancer surgery: historical background and perspective in Western countries versus Japan.

Authors:  Chun-Dong Zhang; Hiroharu Yamashita; Yasuyuki Seto
Journal:  Ann Transl Med       Date:  2019-09

2.  Adverse prognostic impact of splenectomy on survival in gastric carcinoma patients: Regression and propensity score matching analysis of 1074 patients.

Authors:  Oh Jeong; Ho Goon Kim; Seong Yeob Ryu; Young Kyu Park; Mi Ran Jung
Journal:  PLoS One       Date:  2018-09-11       Impact factor: 3.240

Review 3.  Disadvantages of Complete No. 10 Lymph Node Dissection in Gastric Cancer and the Possibility of Spleen-Preserving Dissection: Review.

Authors:  Tetsuro Toriumi; Masanori Terashima
Journal:  J Gastric Cancer       Date:  2020-02-27       Impact factor: 3.720

4.  Necessity of prophylactic splenic hilum lymph node clearance for middle and upper third gastric cancer: a network meta-analysis.

Authors:  Gaozan Zheng; Jinqiang Liu; Yinghao Guo; Fei Wang; Shushang Liu; Guanghui Xu; Man Guo; Xiao Lian; Hongwei Zhang; Fan Feng
Journal:  BMC Cancer       Date:  2020-02-24       Impact factor: 4.430

  4 in total

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