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Literature DB >> 23266890

Chemical approaches to studying stem cell biology.

Wenlin Li¹, Kai Jiang, Wanguo Wei, Yan Shi, Sheng Ding.

Abstract

Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipulate stem cell fates is essential to understand the basic mechanisms of stem cell biology, and to translate stem cells into regenerative medicine. Chemical approaches have recently provided a number of small molecules that can be used to control cell self-renewal, lineage differentiation, reprogramming and regeneration. These chemical modulators have been proven to be versatile tools for probing stem cell biology and manipulating cell fates toward desired outcomes. Ultimately, this strategy is promising to be a new frontier for drug development aimed at endogenous stem cell modulation.

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Year: 2012 PMID： 23266890 PMCID： PMC3541662 DOI： 10.1038/cr.2012.182

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

83 in total

1. Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.

Authors: Rodolfo Gonzalez; Jae Wook Lee; Peter G Schultz
Journal: Angew Chem Int Ed Engl Date: 2011-11-18 Impact factor: 15.336

2. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Authors: Anthony E Boitano; Jian Wang; Russell Romeo; Laure C Bouchez; Albert E Parker; Sue E Sutton; John R Walker; Colin A Flaveny; Gary H Perdew; Michael S Denison; Peter G Schultz; Michael P Cooke
Journal: Science Date: 2010-08-05 Impact factor: 47.728

3. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.

Authors: Tao Wang; Keshi Chen; Xiaoming Zeng; Jianguo Yang; Yun Wu; Xi Shi; Baoming Qin; Lingwen Zeng; Miguel Angel Esteban; Guangjin Pan; Duanqing Pei
Journal: Cell Stem Cell Date: 2011-11-17 Impact factor: 24.633

4. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.

Authors: Terri T Ni; Eric J Rellinger; Amrita Mukherjee; Shuying Xie; Lauren Stephens; Curtis A Thorne; Kwangho Kim; Jiangyong Hu; Ethan Lee; Larry Marnett; Antonis K Hatzopoulos; Tao P Zhong
Journal: Chem Biol Date: 2011-12-23

5. Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

Authors: Saiyong Zhu; Wenlin Li; Hongyan Zhou; Wanguo Wei; Rajesh Ambasudhan; Tongxiang Lin; Janghwan Kim; Kang Zhang; Sheng Ding
Journal: Cell Stem Cell Date: 2010-12-03 Impact factor: 24.633

6. Development of proneurogenic, neuroprotective small molecules.

Authors: Karen S MacMillan; Jacinth Naidoo; Jue Liang; Lisa Melito; Noelle S Williams; Lorraine Morlock; Paula J Huntington; Sandi Jo Estill; Jamie Longgood; Ginger L Becker; Steven L McKnight; Andrew A Pieper; Jef K De Brabander; Joseph M Ready
Journal: J Am Chem Soc Date: 2011-01-06 Impact factor: 15.419

7. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.

Authors: Wenlin Li; Woong Sun; Yu Zhang; Wanguo Wei; Rajesh Ambasudhan; Peng Xia; Maria Talantova; Tongxiang Lin; Janghwan Kim; Xiaolei Wang; Woon Ryoung Kim; Stuart A Lipton; Kang Zhang; Sheng Ding
Journal: Proc Natl Acad Sci U S A Date: 2011-04-27 Impact factor: 11.205

8. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

Authors: Luigi Warren; Philip D Manos; Tim Ahfeldt; Yuin-Han Loh; Hu Li; Frank Lau; Wataru Ebina; Pankaj K Mandal; Zachary D Smith; Alexander Meissner; George Q Daley; Andrew S Brack; James J Collins; Chad Cowan; Thorsten M Schlaeger; Derrick J Rossi
Journal: Cell Stem Cell Date: 2010-09-30 Impact factor: 24.633

9. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.

Authors: Matthias Stadtfeld; Effie Apostolou; Francesco Ferrari; Jiho Choi; Ryan M Walsh; Taiping Chen; Steen S K Ooi; Sang Yong Kim; Timothy H Bestor; Toshi Shioda; Peter J Park; Konrad Hochedlinger
Journal: Nat Genet Date: 2012-03-04 Impact factor: 38.330

10. Energy metabolism in human pluripotent stem cells and their differentiated counterparts.

Authors: Sandra Varum; Ana S Rodrigues; Michelle B Moura; Olga Momcilovic; Charles A Easley; João Ramalho-Santos; Bennett Van Houten; Gerald Schatten
Journal: PLoS One Date: 2011-06-17 Impact factor: 3.240

12 in total

Review 1. Generation of pluripotent stem cells without the use of genetic material.

Authors: Akon Higuchi; Qing-Dong Ling; S Suresh Kumar; Murugan A Munusamy; Abdullah A Alarfaj; Yung Chang; Shih-Hsuan Kao; Ke-Chen Lin; Han-Chow Wang; Akihiro Umezawa
Journal: Lab Invest Date: 2014-11-03 Impact factor: 5.662

2. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells.

Authors: Julien Maruotti; Srinivas R Sripathi; Kapil Bharti; John Fuller; Karl J Wahlin; Vinod Ranganathan; Valentin M Sluch; Cynthia A Berlinicke; Janine Davis; Catherine Kim; Lijun Zhao; Jun Wan; Jiang Qian; Barbara Corneo; Sally Temple; Ramin Dubey; Bogdan Z Olenyuk; Imran Bhutto; Gerard A Lutty; Donald J Zack
Journal: Proc Natl Acad Sci U S A Date: 2015-08-12 Impact factor: 11.205

3. Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons.

Authors: Zixiao Shi; Tianjin Shen; Yanli Liu; Yuanyuan Huang; Jianwei Jiao
Journal: J Biol Chem Date: 2014-01-23 Impact factor: 5.157

4. Regenerative medicinal chemistry: the in situ control of stem cells.

Authors: Angela J Russell
Journal: ACS Med Chem Lett Date: 2013-03-27 Impact factor: 4.345

Review 5. Toward in Vitro Production of Platelet from Induced Pluripotent Stem Cells.

Authors: Elaheh Izady; Zohreh Saltanatpour; Li-Ping Liu; Akram Alizadeh; Amir Ali Hamidieh
Journal: Stem Cell Rev Rep Date: 2022-04-09 Impact factor: 6.692

6. A hybrid-membrane migration method to isolate high-purity adipose-derived stem cells from fat tissues.

Authors: Akon Higuchi; Ching-Tang Wang; Qing-Dong Ling; Henry Hsin-chung Lee; S Suresh Kumar; Yung Chang; Abdullah A Alarfaj; Murugan A Munusamy; Shih-Tien Hsu; Gwo-Jang Wu; Akihiko Umezawa
Journal: Sci Rep Date: 2015-05-13 Impact factor: 4.379

7. Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming.

Authors: Simon E Vidal; Bhishma Amlani; Taotao Chen; Aristotelis Tsirigos; Matthias Stadtfeld
Journal: Stem Cell Reports Date: 2014-10-14 Impact factor: 7.765