PURPOSE: To survey compliance with recommended intravitreal ranibizumab treatment protocols in daily clinical practice in France, with reference to outcomes. METHODS: A retrospective, descriptive, observational study in patients with subfoveal wet age-related macular degeneration treated with ranibizumab. All historical data for the study period, including demographic, treatment, and disease details and visual acuity measurements (baseline, Month 3, and Month 12), were recorded retrospectively at least 12 months after the beginning of treatment. RESULTS: In 551 patients followed by 16 ophthalmologists, 12 months of intravitreal ranibizumab treatment induced a mean visual acuity gain of 3.2 ± 14.8 Early Treatment Diabetic Retinopathy Study-equivalent letters. Fewer than 40% of patients received the recommended treatment of initial 3 monthly injections. More than 50% had to wait >8 days between diagnosis and treatment. At Month 3, visual acuity gain was greater in patients who had received recommended induction and in whom treatment was initiated quickly. At Month 12, the induction-related effect had largely disappeared but the time-to-treatment effect persisted. Patients had an average of 5.1 injections (2.6 during induction period). No patients were monitored monthly as stipulated in the guidelines. CONCLUSION: Although poor compliance with recommendations has been reflected in mediocre outcomes, there is evidence that practice is improving.
PURPOSE: To survey compliance with recommended intravitreal ranibizumab treatment protocols in daily clinical practice in France, with reference to outcomes. METHODS: A retrospective, descriptive, observational study in patients with subfoveal wet age-related macular degeneration treated with ranibizumab. All historical data for the study period, including demographic, treatment, and disease details and visual acuity measurements (baseline, Month 3, and Month 12), were recorded retrospectively at least 12 months after the beginning of treatment. RESULTS: In 551 patients followed by 16 ophthalmologists, 12 months of intravitreal ranibizumab treatment induced a mean visual acuity gain of 3.2 ± 14.8 Early Treatment Diabetic Retinopathy Study-equivalent letters. Fewer than 40% of patients received the recommended treatment of initial 3 monthly injections. More than 50% had to wait >8 days between diagnosis and treatment. At Month 3, visual acuity gain was greater in patients who had received recommended induction and in whom treatment was initiated quickly. At Month 12, the induction-related effect had largely disappeared but the time-to-treatment effect persisted. Patients had an average of 5.1 injections (2.6 during induction period). No patients were monitored monthly as stipulated in the guidelines. CONCLUSION: Although poor compliance with recommendations has been reflected in mediocre outcomes, there is evidence that practice is improving.
Authors: B Heimes; F Gunnemann; M Ziegler; M Gutfleisch; G Spital; D Pauleikhoff; A Lommatzsch Journal: Ophthalmologe Date: 2016-11 Impact factor: 1.059
Authors: Kun Ding; Jikui Shen; Zibran Hafiz; Sean F Hackett; Raquel Lima E Silva; Mahmood Khan; Valeria E Lorenc; Daiqin Chen; Rishi Chadha; Minie Zhang; Sherri Van Everen; Nicholas Buss; Michele Fiscella; Olivier Danos; Peter A Campochiaro Journal: J Clin Invest Date: 2019-08-13 Impact factor: 14.808
Authors: Eda I Altiok; Jorge L Santiago-Ortiz; Felicia L Svedlund; Aline Zbinden; Amit K Jha; Deepika Bhatnagar; Peter Loskill; Wesley M Jackson; David V Schaffer; Kevin E Healy Journal: Biomaterials Date: 2016-03-12 Impact factor: 12.479
Authors: Sean F Hackett; Jie Fu; Yoo Chun Kim; Hiroki Tsujinaka; Jikui Shen; Raquel Lima E Silva; Mahmood Khan; Zibran Hafiz; Tao Wang; Matthew Shin; Nicole M Anders; Ping He; Laura M Ensign; Justin Hanes; Peter A Campochiaro Journal: Biomaterials Date: 2020-03-04 Impact factor: 12.479