| Literature DB >> 23266549 |
A Laux-Biehlmann1, J Mouheiche, J Vérièpe, Y Goumon.
Abstract
Morphine derived from Papaver somniferum is commonly used as an analgesic compound for pain relief. It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian cells from dopamine. Morphine binds mu opioid receptor and induces antinociceptive effects. However, the exact role of these compounds is a matter of debate although different links with infection, sepsis, inflammation, as well as major neurological pathologies (Parkinson's disease, schizophrenia) have been proposed. The present review describes endogenous morphine and morphine derivative discovery, synthesis, localization and potential implications in physiological and pathological processes.Entities:
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Year: 2012 PMID： 23266549 DOI： 10.1016/j.neuroscience.2012.12.013
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590