Literature DB >> 23266292

Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.

Eduardo Pauls1, Ester Ballana, José A Esté.   

Abstract

SAMHD1 (sterile alpha motif and histidine/aspartic acid (HD) domain-containing protein 1) has been identified as a novel HIV-1 restriction factor in myeloid cells and resting CD4+ T lymphocytes. SAMHD1 restriction is antagonized by the lentiviral protein Vpx. Here, we comment on the latest knowledge of SAMHD1 biology, focusing on how it regulates the pool of intracellular nucleotides to control HIV replication. We discuss how HIV restriction by SAMHD1 and viral counter-restriction mechanisms may suggest new strategies for therapeutic intervention.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23266292     DOI： 10.1016/j.antiviral.2012.12.009

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  8 in total

1.  Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells.

Authors:  Joseph A Hollenbaugh; Susan M Schader; Raymond F Schinazi; Baek Kim
Journal:  Virology       Date:  2015-08-29       Impact factor: 3.616

2.  Characterization of the influence of mediator complex in HIV-1 transcription.

Authors:  Alba Ruiz; Eduardo Pauls; Roger Badia; Eva Riveira-Muñoz; Bonaventura Clotet; Ester Ballana; José A Esté
Journal:  J Biol Chem       Date:  2014-08-06       Impact factor: 5.157

3.  p21 regulates the HIV-1 restriction factor SAMHD1.

Authors:  Eduardo Pauls; Alba Ruiz; Eva Riveira-Muñoz; Marc Permanyer; Roger Badia; Bonaventura Clotet; Oliver T Keppler; Ester Ballana; Jose A Este
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-07       Impact factor: 11.205

4.  Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages.

Authors:  Alba Ruiz; Eduardo Pauls; Roger Badia; Javier Torres-Torronteras; Eva Riveira-Muñoz; Bonaventura Clotet; Ramon Martí; Ester Ballana; José A Esté
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

5.  Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

Authors:  Joseph A Hollenbaugh; Catherine Montero; Raymond F Schinazi; Joshua Munger; Baek Kim
Journal:  Virology       Date:  2016-02-16       Impact factor: 3.616

6.  SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.

Authors:  Ester Ballana; Roger Badia; Gerard Terradas; Javier Torres-Torronteras; Alba Ruiz; Eduardo Pauls; Eva Riveira-Muñoz; Bonaventura Clotet; Ramon Martí; José A Esté
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

7.  Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.

Authors:  Roger Badia; Guillem Angulo; Eva Riveira-Muñoz; Maria Pujantell; Teresa Puig; Cristina Ramirez; Javier Torres-Torronteras; Ramón Martí; Eduardo Pauls; Bonaventura Clotet; Ester Ballana; José A Esté
Journal:  J Antimicrob Chemother       Date:  2015-11-04       Impact factor: 5.790

Review 8.  Mouse knockout models for HIV-1 restriction factors.

Authors:  Jan Rehwinkel
Journal:  Cell Mol Life Sci       Date:  2014-05-23       Impact factor: 9.261
  8 in total

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